卡巴匹林钙解热、镇痛、抗炎作用及毒性的观察  

STUDY ON ANTIPYRETIC, ANALGESIC, ANTI INFLAMMATORY AND TOXIC EFFECTS OF CARBASALATE CALCIUM

作　　者：刘国华[1] 韩莹[1] 范学林 

机构地区：[1]山东省药品检验所

出　　处：《中国医药工业杂志》1997年第10期452-453,共2页Chinese Journal of Pharmaceuticals

摘　　要：卡巴匹林钙对实验性家兔发热模型具有良好而稳定的退热作用，它能明显抑制化学、热刺激所致的疼痛，降低角叉药胶所致的大鼠足跖肿胀程度，并抑制棉球肉芽增生。其解热、镇痛、抗炎作用均略优于或相当于阿司匹林。小鼠ｐｏ给药的ＬＤ５０为１７２５ｍｇ／ｋｇ。Carbasalate calcium exerted a stable and prolonged antipyretic effect in experimental fever models. It had a strong inhibitory effect on pain induced by chemical and heat stimulations. It significantly reduced rat paws edema induced by carrageen as well as granulation proliferation caused by cotton pellets. Its antipyretic, analgesic and anti inflammatory effects are slightly better than or equal to aspirin. Its LD 50 (mice,po) is 1725 mg/kg.

关 键 词：卡巴匹林钙 解热 镇痛 抗炎 

分 类 号：R971.1[医药卫生—药品]