HEXIM对转录延伸的调控及其在人类疾病中的作用  

Roles of HEXIM in Regulation of Transcription Elongation and Human Diseases

作　　者：郭明日[1] 曾卫民[1] 陈汉春[1] 

机构地区：[1]中南大学生物科学与技术学院生物化学研究所,长沙410078

出　　处：《中国生物化学与分子生物学报》2008年第9期783-787,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.30070355;30371660)资助~~

摘　　要：环六亚甲基二乙酰胺诱导蛋白(hexamethylene bis-acetamide-inducible protein,HEXIM)是新近发现的参与转录延伸调控的蛋白质,包括HEXIM1和HEXIM2两种同源物.两者均为dsRNA结合蛋白,常以二聚体形式存在,且在调控真核生物RNA聚合酶Ⅱ所催化的转录延伸中功能互补.HEXIM主要通过与7SK snRNA结合,再与正性转录延伸因子b(positive transcription elongation factor b,P-TEFb)形成复合物,抑制P-TEFb的激酶活性,进而抑制转录延伸.近年来发现,HEXIM的转录延伸调控作用参与了人类AIDS、心肌肥大、恶性肿瘤等多种疾病的发生、发展过程.开展以HEXIM为分子靶标的新药研发将为相关疾病的治疗开辟新的途径.Hexamethylene bis-acetamide-inducible protein（HEXIM）is a newly discovered protein that plays a role in regulation of transcription elongation.Two homologues of HEXIM,HEXIM1 and HEXIM2,are both dsRNA-binding proteins and often exist as dimers.They are functionally complementary in the regulation of transcription elongation catalyzed by eukaryotic RNA polymeraseⅡ.HEXIM inhibits transcription elongation mainly through the inhibition of P-TEFb activity when it binds to 7SK snRNA and consequently forms a complex with P-TEFb.It has been found in recent years that HEXIM proteins are strongly correlated to the onset and development of several diseases,such as AIDS,cardiac hypertrophy,malignant tumors,etc.Thus HEXIM can be considered a potential molecular target to develop new drugs for the treatment of these diseases.

关 键 词：环六亚甲基二乙酰胺诱导蛋白(HEXIM) P-TEFB 转录延伸 疾病 分子靶标 

分 类 号：Q71[生物学—分子生物学]