Preparation of poly-L-lactide/bioactive glass composite and evaluation of cytotoxicity in vitro  

作　　者：周智华 阮建明 邹俭鹏 周忠诚 陈良龙 

机构地区：[1]State Key Laboratory of Powder Metallurgy,Central South University [2]College of Chemistry and Chemical Engineering,Hunan University of Science and Technology [3]Department of Orthopedics,the Second Xiangya Hospital,Central South University

出　　处：《中国有色金属学会会刊：英文版》2008年第5期1151-1156,共6页Transactions of Nonferrous Metals Society of China

基　　金：Project(50771096) supported by the National Natural Science Foundation of China

摘　　要：Bioactive and bioresorbable composite materials were fabricated from poly-L-lactide and bioactive glass (average particle size 6.8 μm) by a solvent evaporation technique.Cellular cultivation in vitro and MTT assay were conducted for evaluating the influence on morphology,growth and proliferation of cultured fibroblasts.The results of cytotoxicity testing show that cells cultured in extracts of PLLA/BG and on the surface of composites demonstrate normal growth and proliferation.The bioactive glass in PLLA composite facilitates both adhesion and proliferation of rat fibroblasts on PLLA/bioactive glass composite film.Bioactive and bioresorbable composite materials were fabricated from poly-L-lactide and bioactive glass （average particle size 6.8 μm） by a solvent evaporation technique. Cellular cultivation in vitro and MTT assay were conducted for evaluating the influence on morphology, growth and proliferation of cultured fibroblasts. The results of cytotoxicity testing show that cells cultured in extracts of PLLA/BG and on the surface of composites demonstrate normal growth and proliferation. The bioactive glass in PLLA composite facilitates both adhesion and proliferation of rat fibroblasts on PLLA/bioactive glass composite film.

关 键 词：生物活性玻璃 复合材料 生物相容性 化学反应 

分 类 号：TB332[一般工业技术—材料科学与工程]