抗抑郁药物治疗心脏神经症效果评估  

Therapeutic efficacy of antidepressants for patients with cardiac neurosis

作　　者：李晓丽[1] 毛家亮[1] 韦彩雯[1] 何奔[1] 陈颖莹[1] 

机构地区：[1]上海交通大学医学院仁济医院心内科,上海200127

出　　处：《上海交通大学学报（医学版）》2008年第9期1134-1136,共3页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市高等学校科学技术发展基金(01B09)~~

摘　　要：目的评估心脏神经症患者躯体化症状和焦虑抑郁情绪的严重程度,及抗抑郁药物在治疗心脏神经症中的作用。方法采用焦虑自评量表(SAS)、抑郁自评量表(SDS)和躯体化症状自评量表(SSS)对心脏神经症患者(病例组,n=105)和体检结果正常的健康人(对照组,n=130)进行评分,观察心脏神经症患者焦虑、抑郁和躯体化症状的严重程度。对病例组应用抗抑郁药物治疗,于治疗的2周末和6周末分别再次评分,评价焦虑、抑郁情绪和躯体化症状的改善程度。结果治疗前病例组各量表得分均显著高于对照组(P<0.01);使用抗抑郁药物治疗2周末和6周末,病例组各量表得分较治疗前均显著降低(P<0.01),且6周末与对照组比较差异无统计学意义(P>0.05)。结论心脏神经症患者焦虑、抑郁情绪和躯体化症状均较明显,抗抑郁药物对治疗心脏神经症有显著疗效。Objective To assess the severity of somatization symptoms and the state of anxiety and depression of patients with cardiac neurosis, and evaluate the therapeutic efficacy of antidepressants for these patients. Methods Self-Rating Anxiety Scale （SAS）, Self-Rating Depression Scale （SDS） and Self-Rating Somatization Symptoms Scale （SSS） were used to evaluate the extent of somatization symptoms, anxiety and depression of patients with cardiac neurois（patient group, n = 105） and healthy adults （control group, n = 130）. Antidepressants were administered to the patients, and the alterations of somatization symptoms, anxiety and depression 2 weeks and 6 weeks after treatment were assessed again. Results The scores of SSS, SAS and SDS of the patients were higher than those of the controls（P 〈 0. O1 ）. The scores of the patients decreased significantly after treatment for 2 and 6 weeks （ P 〈 0. O1 ）. There was no significant difference in the scores between the patient group and control group after treatment for 6 weeks （ P 〉 0.05 ）. Conclusion The somatization symptoms, state of anxiety and depression were common in patients with cardiac neurosis, and the antidepressants were effective in the treatment of cardiac neurosis.

关 键 词：心脏神经症 抗抑郁药 躯体化症状 

分 类 号：R541[医药卫生—心血管疾病]