蜂房提取物对荷瘤鼠放化疗的增效作用  

The Synergistic Effects of Honeybee-hives Extractives to Chemotherapy and Radiotherapy of Mice with Transplanted Carcinoma

作　　者：魏金荣[1] 张坤[1] 关一夫[1] 张岐山[2] 

机构地区：[1]中国医科大学基础医学院生物化学与分子生物学教研室,辽宁沈阳110001 [2]中国医科大学药学院生物制药研究室,辽宁沈阳110001

出　　处：《贵阳医学院学报》2008年第5期462-464,共3页Journal of Guiyang Medical College

基　　金：辽宁省教育厅高等学校科学技术研究项目(编号05L529)

摘　　要：目的:观察蜂房乙醇提取物对荷H22肝癌小鼠的放化疗增效作用。方法:移植H22肝癌的小鼠模型,给予蜂房乙醇提取物与化疗和放疗联合,计算抑瘤率及增效率。结果:蜂房乙醇提取物对荷H22肝癌小鼠放化疗的抑瘤率分别达60.5%和61.2%,增效率分别为33.3%和32.6%。结论:蜂房乙醇提取物对荷H22肝癌小鼠的放化疗均有明显的增效作用。Objective： To study the synergistic effects of ethanol extracts from honeybee hives on the therapeutic efficacy of chemotherapy and radiotherapy to transplanted H22 hepatoma in mice. Methods： The mice model transplanted with H22 hepatoma and received chemotherapy or radiotherapy treatment were fed with 85% ethanol extracts from honeybee hives for 15 days. After the treatment stopped, the masses of H22 hepatoma taken from the mice were weighed and the repression rates of tumor and the enhanced therapeutic efficacy were evaluated. Results： With radiotherapy and chemotherapy the repression rates of H22 hepatoma in mice treated with the ethanol extracts were 61.2% and 60.5%, and the enhanced therapeutic rates were 32.6% and 33.3%, respectively. Conclusions： Ethanol extracts from honeybee hives have effects to enhance the therapeutic efficacy of chemotherapy or radiotherapy treatment on transplanted H22 hepatoma in mice.

关 键 词：肝肿瘤 实验性 小鼠 蜂房提取物 H22肝癌 

分 类 号：R285.5[医药卫生—中药学]