双歧杆菌及灵芝孢子对胃肠菌群失调的预防  

The Preventive Effect of Ganoderma Spore Powder and Bifidobacteria on Intestinal Microflora Imbalance of Mice

作　　者：龙世棋[1] 左丽[1] 陈阿英[1] 崔冬冰[1] 钟志强[1] 

机构地区：[1]贵阳医学院免疫学教研室,贵州贵阳550004

出　　处：《贵阳医学院学报》2008年第5期488-490,494,共4页Journal of Guiyang Medical College

摘　　要：目的:探讨双歧杆菌、赤灵芝孢子及其联合制剂对小鼠胃肠菌群失调的预防作用,为临床用药提供实验依据。方法:用不同剂量双歧杆菌、灵芝孢子粉及其联合制剂灌胃7d,然后林可霉素连续灌胃7d,计数直肠成型粪便菌落。结果:(1)各预防组需氧及厌氧菌落数均明显高于菌群失调组(P<0.01);(2)双歧高剂量组需氧菌落数较正常对照组差异无显著性(P>0.05);(3)灵芝孢子高剂量组厌氧菌落数较正常对照组差异无显著性(P>0.05);中、低剂量组需氧菌落数较正常对照组差异无显著性(P>0.05);(4)联合制剂高剂量组厌氧菌落数较正常对照组差异无显著性(P>0.05)。结论:双歧杆菌、赤灵芝孢子、联合制剂有一定预防菌群失调作用。Objective： To investigate the preventive effects of bifidobaeterium, Ganoderma lucidium spore and their combination in alteration of intestinal flora of mouse. Methods： Mice were given orally with bifidobaeterium, Ganoderma spore or combination of the both for 7 days. Then, intragastric administration was carried out with lincomycin to the mice for other 7 days. The microbe colonies obtained from the rectum shaped stool were counted. Result： 1. Colony numbers of aerobian and anaerobian in experimental groups were bigger than those in intestinal flora disorder group （ P 〈 0.01 ） ; 2. Aerobian colony numbers in high dosage bifidobaeterium group did not differ from that of control group （P 〉 0.05 ） ; 3. Anaerobian colony number in high dosage of G. lucidium spore group did not differ from that of control group （ P 〉 0.05 ） ; Aerobian colony numbers in middle and low dosage of G. lucidium spore groups did not differ from that of control group （ P 〉 0.05 ） ; 4. Anaerobian colony number in high dosage of combination group did not differ from that of control group （ P 〉 0. 05 ）. Conclusion： bifidobaeterium, G. lucidium spore and their combination have preventive effects on alteration of intestinal flora in mouse.

关 键 词：胃肠疾病 细菌 厌氧 灵芝 小鼠 肠道菌群失调 双歧杆菌 灵芝孢子 

分 类 号：R285.5[医药卫生—中药学]