新型双大环二正丁基锡羧酸酯的合成、晶体结构及生物活性  

Synthesis,Crystal Structure and Biological Activities of the Novel Dimacrocyclic Di-n-butyltin Carboxylates

作　　者：王艳华[1] 杜锡光[1] 吴晓燕[1] 朱超光[1] 杜大峰[1] 朱东升[1] 

机构地区：[1]东北师范大学化学学院,长春130024

出　　处：《高等学校化学学报》2008年第9期1781-1785,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:200472014);中国博士后科学基金(批准号:2005038561);吉林省科学技术厅科研基金(批准号:20060571;20070406)资助

摘　　要：在乙醇钠催化下,将3-(1,2亚丙二硫基)亚甲基-2,4-二羰基戊烷与2-羰基苯氧乙酸进行缩合反应,获得了柔性二元酸配体1[4-(1,2-亚丙二硫基)亚甲基-3,5-二羰基-1,6-庚二烯-1,7-二(2-羰基苯)氧乙酸(LH2)].再将配体1与二正丁基氧化锡进行脱水反应,获得新型二正丁基锡羧酸酯配合物2.采用元素分析、1H NMR、IR及晶体结构测定等手段对配体1和配合物2进行了结构表征,配合物2是以菱形环Sn2O2为中心对称的二聚体结构,中心菱形环通过氧原子与2个环外锡原子相连.每个羧基分别与环内锡和环外锡原子配位,形成2个对称的六元环,3个环呈梯形排列,将整个分子分割成2个对称的二十二元大环.初步研究了其杀菌活性和抗癌活性.4-（1,2-Dithiopropylene） methylene-3,5-dioxo-1,6-heptadiene-1,7-di-o-phenoxyacetic acid （ 1 ） was synthesized through the reaction of 3-（1,2-dithiopropylene） methylene-2,4-dioxo pentane with 2-formylphenoxyacetic acid under the catalysis of sodium ethoxide. The new di-n-hutyltin carboxylate complex 2 was synthesized by the reaction of the complex 1 with di-n-butyltin oxide. Ligand 1 and complex 2 were characterized via elemental analysis, ^1H NMR, IR and X-ray single crystal diffraction. The structure of complex 2 is a centrosymmetric dimer built up around the rhombus cyclic Sn2O2 four-membered ring, and the rhombus ring joins two exo-cyclic Sn atoms by O atoms. Each carboxyl group was coordinated with endo- and exo-cyclic Sn atoms respectively forming two symmetric six-membered ring. The three rings are in trapezoidal arrangement dividing the complex 2 into two big symmetric twenty-two membered ring. The complex shows antibiotic and anti-tumour activities in vitro experiments.

关 键 词：有机锡(Ⅳ) 双大环二正丁基锡羧酸酯 晶体结构 杀菌活性 抗癌活性 

分 类 号：O624[理学—有机化学] O641[理学—化学]