四君子汤对脾虚大鼠胃粘膜细胞酶组织化学及血浆胃肠激素的影响  

Effects of Sijunzi Decoction on Enzymatic Histochemistry of Gastric Mucosa Cells and Plasma Gastrointestinal Hormone in the Rat with Splenic Deficiency

作　　者：易崇勤[1] 叶百宽[1] 金敬善[2] 堀口贞次郎 江崎宣久 陈文为[1] 

机构地区：[1]北京中医药大学中心实验室,北京100029 [2]北京市中医研究所,北京100010 [3]日本国养命酒制造公司中央研究所

出　　处：《北京中医药大学学报》1997年第6期31-34,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家教委博士学科点科研基金! (No .2 1910 1);日本国养命酒制造公司中央研究所资助

摘　　要：用大承气汤加饥饱失常饮食塑造大鼠消化功能紊乱的脾虚模型 ,观察四君子汤对大鼠胃粘膜细胞形态学、酶组织化学和胃肠激素的影响。结果 ,模型组大鼠胃粘膜细胞受损 ,CA和SDH以及ATPase活性降低 ,血浆胃泌素水平下降 ,胃动素和胰高血糖素升高 ;四君子汤组大鼠上述指标均得以明显改善而接近对照组。说明四君子汤可能通过保护胃粘膜细胞 ,调整胃肠激素的分泌 ,促进胃肠道对葡萄糖等营养物质的吸收 ,继之改善机体的物质能量代谢而发挥对机体整体的调节效应。Splenic deficiency model was induced in rats by giving Dachengqi Decoction plus irregular feeding, and the effects of Sijunzi Decoction on rat morphology and enzymatic histochemistry of gastric mucosa, and on gastrointestinal hormone, were observed. The results showed that in the model group, the activity of CA, SDH and ATPase was decreased, the level of plasma gastrin was lowered, and the levels of motilin and pancreatic glucagon were increased; in the Sijunzi Decoction group, all above-mentioned criteria were obviously improved and were close to those determined in the control group.

关 键 词：四君子汤 酶组织化学 胃肠激素 脾虚 

分 类 号：R289.5[医药卫生—方剂学] R256.305[医药卫生—中药学]