逐瘀化痰汤等三方对大鼠脑出血脑组织MDA、Ca^(2+)、Fe^(2+)影响的实验研究  

Experimental Study on the Effects of Three TCM Formulas Including Zhuyuhuatan Decoctionon the MDA、 Ca^(2+) and Fe^(2+) in the Brain of the Rat with Cerebral Hemorrhage

作　　者：杨万章 万中民 李明富[3] 张发荣[3] 

机构地区：[1]广东省深圳市南山人民医院,广东518051 [2]陕西中药研究所,陕西712000 [3]成都中医药大学,四川610075

出　　处：《北京中医药大学学报》1997年第6期35-37,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助课题! (No .3 8870 92 6)

摘　　要：采用高脂血症大鼠脑内注血模型 ,比较运用逐瘀化痰汤、三生饮、抵当汤三方对注血后脑组织中自由基衍生物丙二醛 (MDA) ,Ca2 +、Fe2 +、脑含水率的效应。结果表明 ,自由基清除作用 ,三生饮优于逐瘀化痰汤、抵当汤 ;Ca2 +拮抗及降低脑含水率作用 ,逐瘀化痰汤优于抵当汤、三生饮 ,均有显著性差异 (P <0 0 5)。给药组Fe2 +升高 ,是活血化瘀药物加速血肿中红细胞破坏、促进血肿吸收的效应 ,无加速自由基反应证据。说明活血化瘀、祛痰利水、益气固脱方药对脑出血后脑损伤具有自由基清除剂及Ca2Hyperlipemic rat intracerebral blood infusion model was used to compare the effects of Zhuyuhuatan Decoction (ZD), Sansheng Decoction (SD) and Didang Decoction (DD) on cerebral MDA, Ca 2+ , Fe 2+ , and water ratio of the rats in the model group. The results showed that the effect of cleansing free radicals of SD was better than that of ZD and DD; the effects of antagonizing Ca 2+ and decreasing cerebral water ratio of ZD were better than those of DD and SD; and the level of Fe 2+ was increased by the effects of speeding the destruction of hematomatic erythrocytes and promoting the absorption of hematoma of the drugs for activating blood circulation to remove stasis contained in the three TCM decoctions. The results suggest that drugs for activating blood circulation to remove stasis, dispelling phlegm and water, and nourishing qi to resist prostration, can act as a free radical scavenger and a Ca 2+ antagonist in the treatment of cerebral lesion due to cerebral hemorrhage.

关 键 词：脑出血 脑组织 MDA 钙拮抗剂 逐瘀化痰汤 中药 

分 类 号：R277.733.1[医药卫生—中医学] R285.5