低硒地区施硒肥粮硒的生物利用率  

OAVAILABILITY OF SELENIUM IN SE-FERTILIZED GRAIN WITHIN Se DEFICIENT AREA

作　　者：卜凤泉[1] 姜熙罗[1] 安汝国 胡秀丽[1] 周余来[1] 刘景英[1] 

机构地区：[1]白求恩医科大学应用基础医学研究所

出　　处：《中国地方病防治》1997年第6期329-331,共3页Chinese Journal of Control of Endemic Diseases

摘　　要：用低硒地区粮饲料(Se0.010mg/kg)、同一地区施硒肥粮饲料(Se0.096mg/kg)和补亚硒酸钠饲料Se0.055mg/kg和Se0.110mg/kg)分别喂养大鼠17周,以T_45′—脱单碘酶(ID—I)活力,谷胱甘肽过氧化物酶(GPx)活力和硒为指标.求得施硒肥粮中硒的相对生物利用率(RBA)。结果表明,硒肥粮硒的RBA,以ID一I活力为指标时,肝、肾中分别为146和170;以GPx活力为指标时,血浆、心、肝和肾中分别为86、182、81和78;以组织硒为指标时,则分别为128、127、142和391。硒肥粮中结合态硒在提高机体硒水平,肝、肾ID—I和心肌GPx活力方面优于亚硒酸钠。Four groups of rats were fed with: (1) the Se-deficient grain basic diet(Se 0. 010 mg/kg ). (2 )the selen-ite-fertilized grain from the same area basal diet (Se 0. 096 mg/kg) , (3)the selenite supplemented grain basal diet(Se 0. 055 mg/kg)and(4)the selenite supplemented grain basal diet(Se 0. 110mg/kg)for 17 weeks. Activities of type-1 iodothyronine deiodinase(ID-I)and glutathione peroxidase(GPx)and selenium levels were used as the indicator to study and calculate the relative bioavailability (RBA)of selenium in Se-fertilized grain. The results indicated that RBA of selenium in Se-fertilized grain,taking activity of ID-I in liver or kidney as the indicator, were 146 and 170,taking GPx activity in plasma, heart, liver and kidney as the indicator , were 86,182,81 and 78, respectively .taking selenium level as the indicator ,were 128,127.142and 391 ,respectively. The natural form of selenium in Se-fertilized grain has an advantage over Na2SeO3 in increasing the body selenium level,ID- I activity in liver or kidney and GPx activity in heart.

关 键 词：克山病 预防 硒肥粮 硒 生物利用率 硒缺乏 

分 类 号：R542.301[医药卫生—心血管疾病] R591.1[医药卫生—内科学]