川芎嗪、乌司他丁和胸腺肽α1对脓毒症患者的免疫调理作用  

Clinical study of altering immunity for Chuanxiongqin ulinastain and thymosin α1 on sepsis patients

作　　者：潘永[1] 徐杰[1] 招兰芝[1] 张斌[1] 陈银结[1] 肖秋生[1] 覃绪[1] 

机构地区：[1]佛山市中医院重症监护病房,广东省佛山528000

出　　处：《中国基层医药》2008年第8期1263-1264,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省佛山市卫生局科研项目（2006085）

摘　　要：目的研究川芎嗪、乌司他丁和胸腺肽α1对脓毒症患者的免疫调理及保护作用。方法90例脓毒症患者随机分为三组，包括ICU治疗组、川芎嗪治疗组、乌司他丁和胸腺肽α1治疗组。观察各组HLA—DR／CD14＋、Lac、IL-6、TNF-α、D-二聚体等指标的变化。结果（1）ICU治疗组和乌司他丁和胸腺肽α1治疗组各时间点D-二聚体无明显变化（P〉0．05）。川芎嗪治疗组D-二聚体呈下降趋势，在3d时，与其他两组差异有统计学意义（P〈0．05）。（2）ICU组各时间点乳酸值无明显变化（P〉0．05）。川芎嗪组和乌司他丁和胸腺肽锄治疗Lac组呈降低趋势，在第2天这两组与ICU组差异有统计学意义（P〈0．05）。（3）在IL-6、TNF-α的变化方面，ICU组各时间点呈上升趋势（P〈0．05）。治疗后第3天，乌司他丁和胸腺肽α1治疗组IL-6、TNF-α恢复治疗前水平，HLA-DR／CD14＋值上升显著，与川芎嗪组、ICU治疗组比较，差异有统计学意义（P〈0．05）。结论川芎嗪主要作用是改善局部微循环，降低乳酸和防止微血栓的形成，乌司他丁、胸腺肽α1对脓毒症患者的免疫具有保护作用，与抑制IL-6、TNF—α细胞因子的作用有关。Objective To investigate the effect of microeirculation blood flow and altering immunity by Chuanxiongqin, ulinastain and thymosin α1 on sepsis patients. Methods 90 patients were randomly divided into 3 groups（ n = 30）, namely ICU group, Chuanxiongqin group, utinastain and thymosin a1 group. HLA-DR/CD14 ＋ and IL-6, TNF-α, Lac, DD were measured. Results （1）DD showed no significant difference at every time point between ICU group and utinastain ＋ thymosin a1 group （ P 〉 0.05 ）. DD decreased in Chuanxiongqin group, and was significantly different from the others on the third day. （2）Lac unchanged significantly at every time point in ICU group （ P 〉 0.05 ）. Lac in Chuanxiongqin group and ulinastain ＋ thymosin α1 group tended to decrease, and was statistically different from ICU group on the second day. （3）IL-6 and TNF-α tended to increase at every time point in ICU group（P 〈 0.05）. In ulinastain ＋ thymosin α1 group, IL-6 and TNF-α returned to the level before treatment, HLA- DR/CD14 ＋ increased significantly,and was higher than Chuanxiongqin group and ICU group statistically. Conclusion Chuanxiongqin could ameliorate circulation; ulinastain and thymosin α1 could depress IL-6, TNF-α. So ulinastain and thymosin α1 might protect the immunity of sepsis patients.

关 键 词：川芎嗪 乌司他丁和胸腺肽α1 脓毒症 免疫调理 

分 类 号：R45[医药卫生—治疗学]