骨碎补总黄酮、淫羊藿总黄酮联合防治小鼠骨质疏松的疗效观察  

Effect of the combination of two kinds of total flavones on osteoporosis mice

作　　者：肖润梅[1] 陈勇[2] 

机构地区：[1]湖北省新华医院药剂科,湖北省武汉430015 [2]湖北大学中药生物技术省重点实验室

出　　处：《中国基层医药》2008年第8期1269-1270,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：湖北大学中药生物技术省重点实验室开放基金资助（2005-0102）

摘　　要：目的研究骨碎补总黄酮、淫羊藿总黄酮对实验性骨质疏松症小鼠骨代谢生化指标的影响。方法采用维甲酸灌胃造成小鼠实验性骨质疏松症模型，同时灌服高、中、低三种剂量的含有骨碎补总黄酮、淫羊藿总黄酮的供试药，检测小鼠血清总碱性磷酸酶（AKP）、羟脯胺酸／肌酐值（HOP／Cr）、钙离子（Ca^2＋）、骨钙素（BGP）的变化。结果三个给供试药剂量组的血清总碱性磷酸酶含量与模型组相比均升高，血清骨钙素、羟脯胺酸／肌酐、血清钙离子与模型组相比均下降（P〈0．01或P〈0．05）。结论骨碎补总黄酮、淫羊藿总黄酮对维甲酸所致小鼠骨质疏松症有一定的防治作用。Objective To study the effects of epimedium koreanum flavones and davallia mariesil flavones on osteoporosis mice induced by retinoic acid. Methods The osteoporosis mice wereinduced by retinoic acid and then were fed with epimedium koreanum flavones and davallia mariesil flavones. The biochemical markers in serum were observed. Results The data showed that the blood AKP were higher in mice treated with two total flavones than mice in model group, tile blood HOP/Cr,BGP, Ca^2＋ were lower in treated mice than model group（ P 〈 0.01 or P 〈 0.05）. Conclusion This study suggests that those two total flavones can effectively treat the osteoporosis mice induced by retinoic acid.

关 键 词：淫羊藿 骨碎补 黄酮类 骨质疏松 维甲酸 

分 类 号：R28[医药卫生—中药学]