叶酸联合甲钴胺治疗尿毒症患者颈动脉粥样硬化的超声研究  

Evaluation of ultrasound on peripheral atheral atherosclerosis after treatment by folicacid in combination with mecobalamin in uremia patient

作　　者：陈祥洪[1] 丁少波[1] 谢玉环[1] 刘自爱[1] 王海[1] 

机构地区：[1]东莞市人民医院超声科,广东省东莞523018

出　　处：《中国基层医药》2008年第8期1278-1279,1409,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的评价超声技术用于检测尿毒症患者颈动脉粥样硬化的临床意义。方法99例伴有颈动脉粥样硬化的尿毒症患者给予口服叶酸片和甲钴胺片，6个月后观察颈动脉中膜的厚度（IMT）、斑块的总面积及双侧颈动脉动脉粥样硬化斑块的数量、超声分型的变化。结果治疗6个月后，患者颈动脉IMT明显变薄（P〈0．05），斑块的总面积减少，动脉粥样硬化斑块的超声分型也发生了变化，斑块数量减少差异有统计学意义（P〈0．05）。结论叶酸联合甲钴胺治疗有助于尿毒症患者颈动脉粥样硬化的转归，应用超声技术检测尿毒症患者颈动脉粥样硬化有助于了解疾病的不同状态，便于判断病情及预后。Objective To evaluate the clinical significance of peripheral atheral atherosclerosis after treatment by folicacid in combination with mecobalamin in uremia patient using vascular ultrasound. Methods 99 cases of uremia patients with carotid atherosclerosis were treated with folic acid tablets and mecobalamin tablets for six months. The carotid intimia-media thickness（ IMT）, total plaque area, numbers and ultrasound types of carotid atherosclerotie before and after treatment were observed. Results After six months,carotid IMT became tinner significantly,and the total plaque area decreased（ P 〈 0.05）. The ultrasound types of carotid atherosclerotic plagues have changed after six months, and the plaque numbers decreased Significantly（P 〈 0.05 ）. Conclusion Threatment by folie acid combination with mecobalamin in uremia patients maybe helpful to the progression of carotid atherosclerotic disease.

关 键 词：尿毒症 动脉粥样硬化 颈动脉 超声检查 叶酸 

分 类 号：R692[医药卫生—泌尿科学] R44[医药卫生—外科学]