他汀类药物对慢性肾功能衰竭患者炎性反应的影响  

Effects of statins on inflammatory reaction in chronic renal failure patients

作　　者：袁园[1] 苏克亮[1] 陈薇[1] 

机构地区：[1]安徽省立医院肾内科,安徽省合肥230001

出　　处：《中国基层医药》2008年第8期1327-1328,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察慢性肾功能衰竭（CRF）患者C-反应蛋白（CRP）、纤维蛋白原（Fg）的变化，探讨他汀类药物对CRF患者炎性反应的影响。方法将54例CRF患者随机平均分为两组：非他汀组予常规治疗；他汀组予常规治疗加普伐他汀20mg／d或辛伐他汀20mg／d。同时设健康对照组20例。测定各组治疗前和治疗4周后CRP、Fg水平。结果CRF患者治疗前CRP、Fg显著高于对照组，差异有统计学意义（P〈0．05）。治疗4周后，他汀组CRP、Fg水平下降，与治疗前及同期非他汀组相比，差异有统计学意义（P〈0．05）。结论（1）CRF患者中存在CRP水平升高的炎性反应；（2）他汀类药物可以降低CRP、Fg水平，提示其具有降脂以外的抗炎作用。Objective To observe the changes of serum CRP and plasma Fg in patients with chronic renal failure（CRF） ,to explore the effect of statins on inflammaory reaction in CRF patients. Methods 54 patients with CRF were randomly divided into non-statins group（routine therapy） ;statins group（ routine therapy plus simvastatin 20mg/d or pravastatin 20mg/d）. Besides, a healthy control group consisted of 20 subjects was set up as control group. The changes of serum of CRP and plasma Fg of all groups before and four weeks after treatment were recorded. Results The serum CRP and plasma Fg levels increased in CRF patients, which were significantly, higher as compared to the control group. After treatment for four weeks,the level of CRP,Fg of statins group decreased significantly. The levels of CRP, Fg had no statistical changes in non-statins group. As compared to non-statins group, the differences of CRP, Fg levels after treatment in statins group were statistically significant respectively. Conclusions （1） Inflammaory reaction is a common condition in non-dialysis patients with CRF; （2）statins show effects on decrease of CRP, Fg level in CRF patients,independently on the effect of decreasing hyperlipemia.

关 键 词：肾衰竭 慢性 C-反应蛋白 纤维蛋白原 他汀类药物 

分 类 号：R692[医药卫生—泌尿科学]