β-环糊精衍生物对昔康类药物的增溶作用  

The Enhanced Solubility of Oxicams through Inclusion by β-Cyclodextrin and Its Derivatives

作　　者：王茹林[1] 孙体健[1] 刁海鹏[1] 李军[1] 

机构地区：[1]山西医科大学化学教研室,太原市新建南路56号030001

出　　处：《光谱实验室》2008年第5期959-962,共4页Chinese Journal of Spectroscopy Laboratory

基　　金：山西省科技厅自然科学基金(NO20051029)

摘　　要：相溶解度法研究了吡罗昔康、美洛昔康和氯诺昔康与β-环糊精(β-CD)、磺丁醚-β-环糊精(SBE-β-CD)和羟丙基-β-环糊精(HP-β-CD)的包合特性。结果表明,昔康类药物与3种环糊精都形成了1∶1的包合物。环糊精包合能力HP-β-CD>SBE-β-CD>β-CD,增溶效应氯诺昔康>美洛昔康>吡罗昔康。The inclusion interaction between piroxicam,meloxicam,lornoxicam and β-CD,SBE- β-CD,HB-β-CD was studied by phase solubility method. The result showed that the 1 ： 1 inclusion compounds were formed beween CDs and oxicam. The binding capacity was in the order HP-β-CD〉 SBE-β-CD〉β-CD. The enhanced solubility of compounds was increased in the order piroxicam〈 melxicam〈lornoxicam.

关 键 词：相溶解度 Β-环糊精衍生物 昔康类药物 溶解度 

分 类 号：O629.12[理学—有机化学] O657.32[理学—化学]