固齿丸对豚鼠实验性牙周损害治疗作用的观察  

Effect of the Chinese Medicine“Guehiwan”on the Impaired Periodontium of Guinea Pigs

作　　者：杨美薷[1] 张举之[1] 肖邦良[2] 

机构地区：[1]华西医科大学口腔医学院 [2]华西医科大学公共卫生学院

出　　处：《华西口腔医学杂志》1990年第3期201-203,共3页West China Journal of Stomatology

基　　金：国家自然科学基金

摘　　要：采用摘除幼龄豚鼠双侧卵巢,并给予维生素 C 不完全缺乏的饲料,造成实验性牙周损害,再用固齿丸及维生素 C 作恢复性实验,观察牙周组织的改变情况。结果表明,固齿丸能抑制破骨细胞,刺激造骨细胞,从而使已损害的豚鼠牙槽骨得以恢复。固齿丸对牙槽骨的代谢可能具有调节作用。Severc destruction of periodontium caused by ovariectomy and subclinical vitamin C(Vit C)dificiency was presented in the young guinea pigs.There were two groups:SY-BVitC and SY-BVitCG,for studying the recovery of the impaired periedontium of theanimals.The SY-BVitC group was supplemented VitC only.And the SY-BVitCG group was treated with Guchiwan(固齿丸)and VitC.No significant difference in the periodontal membrane was shown in either of thetwo groups.A significant difference in the alveolar bone was indicated in SY-BVitCG group as compared with SY-BVitC group.The osteoclasts were reduced(P<0.01)and the osteoblasts increased in the SY-BVitCG group.It is suggested that Guchiwan mayregulate the metabolism of alveolar bone and keep the physiologic equilibrium of alveo-lar bone.

关 键 词：固齿丸 牙周炎 骨槽骨代谢 

分 类 号：R285.5[医药卫生—中药学]