Theoretical Models of Cell Inactivation by Ionizing Particles  

作　　者：CAO Tian-guang MA Yun-zhi KONG Fu-quan YANG Ming-jian ZHUO Yi-zhong 

机构地区：[1]Key Lab of Medical Physics and Engineering, Peking University, Beijing 100871, China [2]School of Sciences, Hebei University of Technology, llanjing 300130, China [3]不详

出　　处：《Annual Report of China Institute of Atomic Energy》2007年第1期92-93,共2页中国原子能科学研究院年报（英文版）

基　　金：National Natural Science Foundation of China (10647146, 10435020, 10175095)

摘　　要：Ionizing radiation can induce various kinds of biological effects, its relative biological effectiveness (RBE) changes not only with the type of radiation and its energy, but also with the type ofIonizing radiation can induce various kinds of biological effects, its relative biological effectiveness （RBE） changes not only with the type of radiation and its energy, but also with the type of biological target and the biological end point concerned. The cell survival curve describes the relationship between the fractional survival of a population of radiated cells and the dose of radiation to which the cells are exposed. The end point for survival in experiments is referred to the ability of a cell to reproduce （reproductive death）. It does not describe the continued existence of a single cell. The theoretical models estimating the fraction of surviving ceils are of the utmost importance to the application of ionizing radiation in radiotherapy.

关 键 词：致电离粒子 细胞失活 理论模型 相对生物效应 致电离辐射 

分 类 号：Q691[生物学—生物物理学]