彩色多普勒超声检测子宫内膜和内膜下血流评价IVF-ET结局  

Assessment of IVF-ET Outcomes by Endometrial and Subendometrial Blood Flows Measured by Vaginal Color Doppler Ultrasound on the Day of hCG Injection

作　　者：李柳铭 吴洪波[1] 袁华[1] 李慕军[1] 

机构地区：[1]广西医科大学第一附属医院生殖医学研究中心,南宁530021

出　　处：《生殖与避孕》2008年第9期558-562,共5页Reproduction and Contraception

基　　金：广西科学研究与技术开发计划项目基金资助(No0236027);广西壮族自治区卫生厅立项科研项目(桂卫Z200558)

摘　　要：目的:探讨hCG注射日应用彩色多普勒超声检测子宫内膜和内膜下血流预测IVF-ET的结局。方法:应用彩色多普勒超声检测hCG注射日子宫内膜和内膜下血流分布情况,将115例IVF-ET/ICSI-ET助孕患者分为A组(n=56):子宫内膜和内膜下均有血流通过;B组(n=42):内膜下有血流但内膜没有血流通过;C组(n=17):内膜和内膜下均无血流通过。随访IVF-ET结局,按妊娠与否分为妊娠组(n=53)与非妊娠组(n=62)。比较A、B、C组的临床特征、卵巢反应、内膜厚度及类型和妊娠结局;比较妊娠组与非妊娠组内膜厚度和类型。结果:A、B、C组间的临床特征、卵巢反应差异无统计学意义,内膜厚度C组低于A组和B组(P<0.05),但3组内膜形态比较差异无统计学意义;A、B、C组妊娠率(62.5%、33.3%、23.5%)和种植率(37.9%、18.4%、10.8%)比较差异有统计学意义(P<0.05)。妊娠组与非妊娠组的内膜厚度及类型比较差异均无统计学意义。结论:hCG注射日应用彩色多普勒超声检测子宫内膜和内膜下血流对IVF-ET的结局有一定的预测价值,是一种较好的、能在临床上普遍开展的无创伤性的预测方法。Objective： To discuss the role of endometrial and subendometrial blood flows measured by vaginal color Doppler ultrasound in the prediction of IVF-ET outcomes on the day of hCG injection. Methods： A total of 54 infertile patients undergoing the IVF/ICST-ET cycle were recruited in this study. The patients were divided into three groups according to a color Doppler ultrasound examination performed on the day of hCG injection. Group A （n=56）, both endometrial and subendometrial blood flow could be detected; group B （n=42）, only subendometrial blood flow could be detected; group C （n=17）, the blood flow could not be detected. Otherwise, all the patients were divided into two groups according to their outcomes of IVF-ET： pregnancy group （n=53： intrauterine pregnancy with live fetus after 4-5 weeks for ET） and non-pregnancy group （n=62）. Demographic data, ovarian responses, endometrial thickness and echo pattern, outcomes of pregnancy were compared. Results： Demographic data, ovarian responses, endometrial echo pattern had no significant difference among the three groups, but endometrial thickness was less in group C than in group A and group B （P〈0.05）.There was significant difference of the rate of pregnancy and implantation among the three groups. There was no significant difference of endometrial thickness and echo pattern between the pregnancy and non-pregnancy groups. Conclusion： Endometrial and subendometrial blood flows is a good predicator of endometrial receptivity and IVF-ET outcomes on the day of hCG injection, so detecting it viginal color Doppler vltrasound on the loay of hCG injcetion is a good non-invasive method.

关 键 词：内膜和内膜下血流 彩色多普勒超声 IVF-ET 结局 

分 类 号：R445.1[医药卫生—影像医学与核医学] R711.74[医药卫生—诊断学]