急性冠脉综合征患者血浆BNP和MCP-1的变化  

Changes of peripheral blood levels of BNP and MCP-1 in patients with acute coronary syndromes

作　　者：胡艳[1] 吕安林[1] 温俊娜[1] 孟小雪[1] 宋延彬[1] 杜鹃鹃[1] 

机构地区：[1]第四军医大学西京医院心脏内科,陕西西安710032

出　　处：《心脏杂志》2008年第5期588-590,共3页Chinese Heart Journal

摘　　要：目的观察急性冠脉综合征(ACS)患者外周血中脑纳尿肽(BNP)及单核细胞趋化蛋白-1(MCP-1)的变化,探讨BNP,MCP-1与ACS的关系。方法住院ACS患者39例,采用ELISA测定血清BNP,MCP-1的水平。结果ACS患者入院即刻血浆BNP和MCP-1水平均显著高于对照组,分别为(560±25)ng/Lvs(42±24)ng/L(P<0.01)和(152±19)ng/Lvs(113±22)ng/L(P<0.01)。ACS组内不稳定心绞痛(UAP)亚组与急性心肌梗死(AM I)亚组比较,AM I亚组BNP水平高于UAP亚组[(557±24)ng/Lvs(172±62)ng/L,P<0.01],而MCP-1水平在AM I亚组和UAP亚组间无显著性差异[(153±19)ng/Lvs(150±22)ng/L]。ACS组患者中BNP和MCP-1水平呈明显正相关(r=0.625,P<0.01)。结论ACS患者外周血BNP和MCP-1水平升高而且两者水平呈正相关。AIM To investigate whether peripheral blood levels of B-type natriuretic peptide （BNP） and monocyte chemoattractant protein-1 （MCP-1） are affected in patients with acute coronary syndromes （ACS）. METHODS Serum BNP and MCP-1 were measured in 38 patients with ACS by enzyme linked immunosorbent assay （ELISA）. RESULTS （1）The serum levels of BNP and MCP-lin ACS group were significantly higher than those in control groups （P 〈0.01, P 〈0. 01 ）. （2）The serum level of BNP were significantly different between UA group and AMI group （P 〈0. 01 ）, but the serum level of MCP-1 was not significantly different between UA group and AMI group. （3）There was an obvious correlation between. BNP and MCP-1 in ACS group （r =0. 625, P 〈 0. 01 ）. CONCLUSION The serum levels of BNP and MCP-1 in patients with coronary artery disease increase and there is an obvious correlation between BNP and MCP-1.

关 键 词：急性冠脉综合征 心肌梗死 急性 心绞痛 不稳定型 脑纳尿肽 单核细胞趋化蛋白-1 

分 类 号：R541.4[医药卫生—心血管疾病]