PET/CT无创检测实验性动脉粥样硬化斑块的初步研究  

Noninvasive imaging of vulnerable plaque with PET/CT:experimental study

作　　者：赵全明[1] 杜慧峰[1] 董小黎[2] 徐占民[1] 王倩[3] 许金鹏[4] 宋爱丽[2] 米洪志[3] 

机构地区：[1]首都医科大学附属北京安贞医院心内科十八病房,北京100029 [2]首都医科大学基础医学院病理系,北京100069 [3]首都医科大学附属北京安贞医院核医学科,北京100029 [4]河北大学医学院附属医院心内科,河北保定710000

出　　处：《中国医学影像技术》2008年第8期1165-1168,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨PET/CT无创检测动脉粥样斑块的可行性。方法6只新西兰大白兔随机分成实验组和对照组。实验组通过球囊拉伤膈下降主动脉内膜,并饲喂含2%胆固醇的高脂饲料20周,制造动脉粥样硬化模型;对照组仅饲喂普通饮食20周。静脉注射FDG(1mCi/kg)180min后,将对照组和实验组动物置于PET/CT设备下进行降主动脉活体成像,之后处死实验组动物,进行降主动脉标本游离,数码照相,降主动脉标本分段,测定其放射强度和靶非靶比值。结果注药180min后18F-FDG PET/CT活体显像显示:所有实验性动脉粥样硬化兔均可见沿降主动脉分布的放射性浓集显像。离体大体标本数码照相病变斑块与活体显像相一致。活体SUV以及离体标本放射性技术显示靶-非靶比值均相对较高。结论18F-FDG PET/CT无创检测动脉粥样斑块具有一定的可行性,有可能发展成为一种临床无创评价斑块稳定性的方法。Objective To study the feasibility of noninvasive detection of vulnerable plaque with ^18F-FDG PET/CT.Methods Inflamed atherosclerotic lesions were induced in 3 male New Zealand white rabbits via deendothelialization of the infradiaphragmatic aorta and exposure to a 20 weeks of high cholesterol diet;3 rabbits fed standard diet without manipulation served as controls.Twenty weeks after balloon injury,animals were injected with FDG labeled with F18（1 mCi/kg）,then the aortic uptake of FDG was assessed（180 minutes after injection）with PET/CT.After the in vivo imaging,aortas were explanted and photographed with digital camera,and F18-FDG uptake analysised by γ counter.Results There was intense uptake of F18-FDG in atherosclerostic group,but no uptake was seen in controls.The results were confirmed in the ex vivo digital photo of the explanted aorta.Quantitative F18-FDG uptake was higher in lesion versus nonlesion areas.Conclusion The accumulation of F18-FDG is in proporation to the metabolic activity of plaque,these data show that measurement of vascular FDG uptake with PET/CT holds promise for the noninvasive detection of unstable atherosclerotic plaques.

关 键 词：PET/CT 不稳定斑块 兔 

分 类 号：R81[医药卫生—放射医学] R-332[医药卫生—临床医学]