正常老年人静息状态脑功能磁共振的默认网络研究  

Study of default-mode network in fMRI in normal elders

作　　者：张洪英[1] 王世杰[2] 杨明[1] 刘斌[1] 马占龙[1] 滕皋军[1] 

机构地区：[1]东南大学附属中大医院放射科,江苏省分子影像与功能影像重点实验室,江苏南京210009 [2]东南大学计算机工程系影像科学与技术实验室,江苏南京210096

出　　处：《中国医学影像技术》2008年第8期1189-1191,共3页Chinese Journal of Medical Imaging Technology

基　　金：东南大学优秀博士基金(YBJJ0728)

摘　　要：目的探讨正常老年人静息状态下的功能磁共振(fMRI)默认网络结构及意义。方法正常健康老年受试者18人,接受静息fMRI扫描;通过时程相关方法检测fMRI数据低频波动信号中以后扣带回为种子区的默认网络,经SPM2软件单样本t检验,激活脑区阈值设为经校正的P<0.001,激活像素范围>5。结果与后扣带回相关的静息状态网络连接的脑区有:前额叶内侧区、海马、颞极、颞中上回、丘脑枕部、楔叶及楔前叶、部分视皮层、顶下小叶。海马区和顶下小叶呈侧化性激活。结论正常老年人存在基本完整的静息状态fMRI默认网络结构,其部分呈侧化性可能是与老年期脑功能重塑有关。Objective To detect the default-mode network in fMRI in normal elders.Methods Eighteen normal elders were performed resting-state fMRI scanning.The default-mode network based on seed region of posterior cingulated cortex was extracted from low frequency fluctuation signal in fMRI data by using a temporal correlation method.Results Brain regions involved in the default-mode network include：medial prefrontal cortex,hippocampus,thalamus,posterior cingulated cortex,temporal pole,superior-medial temporal cortex,cuneus/precuneus,visual cortex,and inferior parietal lobe.The default network shows lateralization in regions of hippocampus and inferior parietal lobe.Conclusion The default-mode network in fMRI in normal elders remains integrated,local lateralization of the network may indicate functional plasticity in elderly brain.

关 键 词：磁共振成像 低频信号波动 默认网络 静息状态 

分 类 号：R445.2[医药卫生—影像医学与核医学]