苯巴比妥钠介入^(99m)Tc-EHIDA肝胆显像诊断先天性胆道闭锁的价值  

Clinical value of ^(99m)Tc-EHIDA hepatobiliary scintigraphy with Phenobarbitol sodium on diagnosis of congential biliary atresia

作　　者：侯先存[1] 程华[2] 李智勇[1] 任少阳[1] 朱辉[1] 

机构地区：[1]徐州医学院附属医院核医学科,江苏徐州221002 [2]徐州医学院附属医院儿科,江苏徐州221002

出　　处：《中国医学影像技术》2008年第8期1261-1263,共3页Chinese Journal of Medical Imaging Technology

摘　　要：目的评价苯巴比妥钠介入99mTc-EHIDA肝胆显像诊断先天性胆道闭锁(BA)的临床价值。方法应用SPECT仪器对58例临床上持续黄疸的婴儿服用苯巴比妥钠,5mg·kg-1.d-1体重,分两次服用,连续一周后行99mTc-EHIDA肝胆显像,并经手术、病理诊断及随访确诊。结果SPECT诊断为BA29例,经临床确诊为BA24例,婴儿肝炎综合征(IHS)5例;SPECT诊断为IHS29例,均经临床随访确诊。SPECT诊断BA的灵敏度为100%,特异性85.3%,准确度91.4%。结论苯巴比妥钠联合99mTc-EHIDA肝胆显像是一种无创、安全、诊断效能高的检查方法,有助于明确病因,预测治疗效果,对于BA的诊断有较高的临床价值。Objective Evaluate the diagnostic value of ^99mTc-EHIDA hepatobiliary scintigraphy with Phenobarbitol Sodium in congential biliary atresia（BA）.Methods Fifty-eight infants with consistent jaundice took Phenobarbitol Sodium（5 mg·kg^-1·d^-1 weight,bid ×7d）,then received ^99mTc-EHIDA hepatobiliary scintigraphy with SPECT instrument,the results of all patients were proved by pathology and clinical follow up results.Results Twenty-nine infants were diagnosed as BA by SPECT.Twenty-four of 29 infants were proved BA and 5 of 29 infants were proved infantile hepatitis syndrome（IHS）;29 infants were diagnosed as IHS by SPECT,and all 29 IHS infants were proved.The sensitivity,specificity and correctrate of this method were 100%,85.3% and 91.4%.Conclusion ^99mTc-EHIDA hepatobiliary scintigraphy with Phenobarbitol Sodium is an anoninvasive,safety,valuable examing method.It will help us definite the etilogy,predict the therapeutic efficacy,and have high clinical value in the diagnosis of BA.

关 键 词：^99MTC-EHIDA 肝胆显像 先天性胆道闭锁 

分 类 号：R657.44[医药卫生—外科学] R81[医药卫生—临床医学]