临床应用型MR大鼠中枢神经系统成像的初步研究  

Preliminary study of MR imaging of the rat central nervous system

作　　者：张海琴[1] 李坤成[1] 于春水[1] 秦文[1] 马佳[1] 

机构地区：[1]首都医科大学宣武医院医学影像学部,北京10053

出　　处：《中国医学影像技术》2008年第9期1352-1355,共4页Chinese Journal of Medical Imaging Technology

基　　金：北京市自然科学基金(7042026);中外医学磁共振交流基金(N4-002)

摘　　要：目的探索临床应用型MR设备进行大鼠中枢神经系统成像的可行性。方法10只健康Lewis大鼠麻醉后取仰卧位在固定装置内完成MR扫描。应用超导型3.0TMR扫描仪（Siemens Trio Tim）及小正交腕关节线圈,分别对大鼠脑和脊髓行T2WI、T1WI和Gd-DTPA增强T1WI的三维容积扫描,体素0.06~0.08mm3。利用工作站专业软件获得脑和脊髓的多方向重组图像。结果大鼠脑T2和T1加权像具有较高的空间分辨率和对比度,胼胝体、小脑、新皮质和脑室等解剖结构显示清楚,脊髓的对比度较弱。多方向重组图像显示大鼠中枢神经系统解剖细节更佳。结论应用3.0T临床型MR设备及正交腕关节线圈可以获得大鼠脑和脊髓高质量MR图像。Objective To explore the feasibility of performing MRI in rat central nervous system （CNS） with clinical whole-body MR scanner. Methods Ten healthy Lewis rats were scanned with 3.0T supper-conductive clinical whole-body MR scanner （Siemens Trio Tim） with a wrist joint coil. The rats were anesthetized and placed into the rat holder in supine position. The T2-weighted, T1-weighted and Gd-DTPA enhanced T1-weighted 3D images of brain and spinal cord were acquired with voxel size in 0.06—0.08 mm3. Then the workstation with special software was used for the reconstruction images of brain and spinal cord of rat in multiple orientations. Results The T2 and T1 weighted images of rat brain with higher spatial and contrast resolution could be obtained, and the anatomical details of corpus callosum, cerebellum, neocortex, and ventricles were clearly visible, but the image contrast of spinal cord was relatively weak. The reconstructed images of multiple orientations could depict the anatomic details of CNS of rat more clearly. Conclusion The high quality MR images can be obtained by 3.0T clinical whole-body MR scanner with quadrature wrist joint coil.

关 键 词：磁共振成像 大鼠 中枢神经系统解剖 

分 类 号：R332[医药卫生—人体生理学] R445.2[医药卫生—基础医学]