对比超声造影与增强CT评价射频凝固闭合性肝外伤疗效的实验研究  

Contrast-enhanced ultrasonography and contrast-enhanced computed tomography in evaluating therapeutic effect of radiofrequency ablation for treating blunt hepatic trauma:a comparative study in pigs

作　　者：程琦[1] 王莎莎[2] 李叶阔[2] 朱贤胜[2] 欧陕兴[3] 刘海凌[3] 成官迅[1] 

机构地区：[1]南方医科大学南方医院影像中心,广东广州510515 [2]广州军区广州总医院超声影像科,广东广州510010 [3]广州军区广州总医院放射科,广东广州510010

出　　处：《中国医学影像技术》2008年第9期1356-1358,共3页Chinese Journal of Medical Imaging Technology

基　　金：广东省自然科学基金(06019712)

摘　　要：目的对比研究超声造影与增强CT评估射频凝固闭合性肝外伤的疗效。方法采用自制小型撞击器撞击8头健康家猪肝区,建立闭合性肝外伤伴活动性出血模型,分为治疗组(6头)和对照组(2头)。治疗组在超声造影引导下进行射频凝固治疗,射频治疗前、后进行超声造影和增强CT检查。对照组撞击后行超声造影和增强CT检查,不进行任何治疗。实验结束后,剖腹验证疗效并将检查结果与病理进行对照。结果治疗前超声造影和增强CT均检出治疗组和对照组全部动物模型的肝实质损伤病灶,超声造影检出全部猪肝活动性出血信号,增强CT检出6头猪肝活动性出血。射频治疗后,治疗组超声造影及增强CT均未检出肝活动性出血。对照组1头在撞击后30分钟内因失血过多死亡,另1头在撞击后1h超声造影及增强CT均可见肝活动性出血。结论超声造影与增强CT均能准确诊断闭合性肝外伤并对射频凝固止血疗效准确评估。Objective To evaluate the therapeutic effect of predaceous radiofrequency （RF） ablation on controlling the hemorrhage of blunt hepatic trauma by using contrast-enhanced ultrasonography （CEUS） and contrast-enhanced computed tomography （CECT）. Methods Eight domestic pigs weighting 38.5-45.8 kg were cracked with self-made impactor in order to create animal models of blunt hepatic traumas. The models were divided into treatment group （n=6） and control group （n=2）. RF ablation was used to control the hemorrhages of the livers in treatment group. The animal models in control group were not treated. CEUS and CECT were performed to detect the livers before and 1 h after RF ablation. The results were compared with pathologic examinations. Results Before RF ablation, injured area in liver parenchyma was detected by CEUS and CECT. Active bleeding from the liver was detected in all pigs by CEUS and six by CECT. After RF ablation, in treatment group, no hemorrhage was found in pigs by CEUS and CECT. In control group, one pig died within 30 minutes after the liver injured. Hemorrhage was still detected by CEUS and CEUT 1 h after the impact. Conclusion CEUS and CECT can exactly evaluate the therapeutic effect of RF ablation on controlling the hemorrhage of the blunt hepatic traumas.

关 键 词：肝 体层摄影术 X线计算机 造影剂 超声检查 

分 类 号：R657.3[医药卫生—外科学] R735.7[医药卫生—临床医学]