结合珠蛋白遗传多态性与特应性皮炎的关系  

Genetic polymorphism and relationship between haptoglobin polymorphism and atopic dermatitis

作　　者：李萍[1] 刘启文[1] 李建红[1] 刘建中[1] 

机构地区：[1]深圳市儿童医院皮肤科,深圳518026

出　　处：《中国麻风皮肤病杂志》2008年第9期680-682,共3页China Journal of Leprosy and Skin Diseases

基　　金：广东省医学科学技术研究基金(B2005117)

摘　　要：目的:检测特应性皮炎(AD)患者血中结合珠蛋白(Hp)表型和Hp基因频率的分布,并分析与病情严重程度之间的关系。方法:采用聚丙烯酰胺凝胶垂直平板电泳技术检测131例AD患者和134例正常对照者血中Hp表型的分布。结果:(1)不同病情严重程度患者之间的Hp表型及Hp基因频率分布无明显差别(P>0.05)。(2)患者组与对照组相比,Hp1-1和Hp2-1明显增高(P<0.05),Hp1基因频率明显增高(P<0.05)。(3)混合性AD组与单纯性AD组相比,Hp1-1和Hp2-1明显增高(P<0.05),Hp1基因频率明显增高(P<0.05)。结论:带有血清Hp2-1和Hp1-1的人群可能对AD有遗传易感性。Hp1基因在AD患者中有聚集现象,与其遗传易感性增高有某种内在联系,可能在AD发病中起一定作用。Objective： To investigate the distribution of senn haptoglobin phenotypes and gene frequency in atopic dermatitis （AD） patients and their relations with the severity of the disease. Methods： The distribution of haptoglobin phenotypes in the serum of 131 AD patients and 134 normal controls were determined by polyacrylamide gel vertical lat- bed electrophoresis. Results： （ 1 ） There was no significant difference between haptoglobin phenotypes and gene frequency among the AD patients with different severity of the disease （P 〉 0.05）. （2） Compared with normal controls, Hp1 - 1 and Hp2- 1 were significantly increased in AD patient group （P 〈 0.05）. Hp^1 allele was also higher （ P 〈 0.05）. （3） Mixed AD patients showed increased frequency of Hp1 - 1, Hp2 - 1 and Hp^1 allele, compared to pure AD patient （P 〈 0.05）. Conclusion： People with Hp1 - 1 and Hp2- 1 may have genetic pretisposition to AD. Hp^1 allele frequency may assemble in AD patients and relate to the increased genetic predisposition of the disease, which may play a role in the pathogenesis of AD.

关 键 词：特应性皮炎 结合珠蛋白 表型 

分 类 号：R758.2[医药卫生—皮肤病学与性病学] R446.112[医药卫生—临床医学]