生殖器念珠菌病致病菌种鉴定及药敏分析  

Identification and drug susceptibility of candida strains from patients with genital candidiasis

作　　者：陈瑞娥[1] 路麒[1] 施岩[1] 郑文华 

机构地区：[1]山东省立医院皮肤性病科,济南250021 [2]济南市疾病控制中心,济南250021

出　　处：《中国麻风皮肤病杂志》2008年第9期683-685,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:了解生殖器念珠菌病的致病菌种及其对常用抗真菌药物的敏感性。方法:采用真菌培养鉴定和药敏试剂盒对73例包皮龟头炎和外阴阴道炎患者临床标本进行菌种分离和药敏检测。结果:73例生殖器念珠菌病的前三位致病菌为白念珠菌(72.6%),近平滑念珠菌(10.96%)和热带念珠菌(6.85%)。7种抗真菌药物的敏感性依次为制霉菌素(69.86%)、5-氟胞嘧啶(67.12%)、两性霉素B(64.38%)、氟康唑(35.62%)、酮康唑(28.77%)、伊曲康唑(21.92%)、咪康唑(16.44%)。结论:本研究显示生殖器念珠菌病的主要致病菌为白念珠菌。制霉菌素、5-氟胞嘧啶、两性霉素B敏感性高,唑类药物敏感性低。Objective： To investigate the main pathogen of genital candidiasis and the susceptibility to antifungal drugs. Methods： Identifcation and drug susceptibility of the 73 Candida strains from patients with genital candidiasis were performed by the fungus identification and susceptibility testing Kit. Results： The main pathogen of 73 strains were Candida albicans （72.6%）, Candidaparopsilosis （10.96%） and Candida tropicalis （6.85%）. The sensitivity rates to nystatin, 5 - flucytosine, amphotericin B, fluconazole, ketoconazole, itraconazole and miconazole were 69.86%, 67.12%, 64.38%, 35.62%, 28.77%, 21.92% and 16.44% respectively. Conclusion： Candida albicans plays the leading role in the genital candidiasis. The sensitivity to nystatin, 5 - flucytosine, amphotericin B was higher, and to miconazole, itraconazole, ketoconazole and fluconazole was lower.

关 键 词：生殖器念珠菌病 念珠菌 抗真菌药物 药敏试验 

分 类 号：R759[医药卫生—皮肤病学与性病学] R446.5[医药卫生—临床医学]