FSH/LH值与控制性超排卵中卵巢反应性关系的临床研究  

Study on the Relationship between the Basal FSH/LH Ratio and Ovarian Response in Controlled Ovarian Hyperstimulation

作　　者：冯玉蓉[1] 黄绘[1] 韦玮[2] 杨雪[1] 文莉[1] 潘世春 

机构地区：[1]贵州省贵阳市妇幼保健院生殖中心,550003 [2]贵州省贵阳市妇幼保健院妇产科,550003

出　　处：《中国计划生育学杂志》2008年第9期562-564,共3页Chinese Journal of Family Planning

摘　　要：目的:探讨FSH/LH值在控制性超排卵(COH)中与卵巢反应性的关系。方法:对336个周期分为超排卵治疗不反应组(34个周期)、低反应组(59个周期)、正常反应组(243个周期),比较3组FSH、LH,以及使用促性腺激素释放激素激动剂(GnRHa)后FSH、LH水平,促性腺激素(Gn)的用量等。激素测定采用酶联免疫分析法。结果:不反应组的FSH基础值为9.9±4.9U/L,分别与低反应组的8.1±5.1U/L及正常反应组的6.6±2.5U/L比较,差异均有统计学意义(P<0.05)。不反应组的FSH/LH基础值为2.8,分别与低反应组(2.1)及正常反应组(1.5)比较差异均有统计学意义(P<0.05)。使用GnRHa启动日不反应组FSH/LH比值为5.1,低反应组为4.1,两者与基础水平比较均有明显增高,而正常反应组增高不明显。结论:GnRHa降调节后,FSH/LH值可用于预测卵巢对Gn的反应性而作为判断COH结果的预测指标。Objective： To study the basal FSH/LH ratio and its changes to prognosticate the ovary response. Methods： 336 regularly cycling patients were divided into three groups： the no response group to the superovulation treatment using gonadotrophin releasing hormone agonist （GnRHa） （ 34 cycles）, the low response group （ 59 cycles）, and the normal response group （243 cycles）. The level of serum follicle stimulating hormone （FSH）, luteinizing hormone （LH） and estradiol （E2 ） were detected using enzyme - linked immuno assay pre - and post - treatment, respectively. And the dosage of gonadotrophin （Gn） was calculated. Results： The basal levels of FSH showed statistical differences （P 〈 0.05 ） among the no response group （9.9 ±4.9 U/L）, the low response group （8. 1 ±5.1 U/L）, and the normal response group （6.6 ±2.5 U/L）. And there were statistical differences （P 〈 0. 05 ） of the basal FSH/LH ratio among the no response （2.8）, the low response group （2.1） , and the normal response group （ 1.5 ）. Compared with the basal level, the FSH/LH ratio of the no response group （5.1） and the low response group （4.1） increased markedly after giving GnRHa, while the ratio of the normal response group showed no significant difference. Conclusion： After giving GnRHa for controlled ovarian hyperatimulation （ COH）, the FSH/LH ratio can used to be a predict index for the effect of COH, for its prognostication of the ovary response to Gn.

关 键 词：超排卵 卵巢 卵泡刺激素(FSH) 黄体生成素(LH) 

分 类 号：R714.8[医药卫生—妇产科学]