血液流变学异常在急性出血坏死性胰腺炎发病机理中的意义  

The Role of Hemorheologic Changes in the Pathogenesis of Acute Hemorrhagic Necrotizing Pancreatitis

作　　者：严律南[1] 张肇达[1] 韦靖江[1] 吴和光[1] 陈槐卿[2] 钟贵辉 李良[2] 陈玲琍 李昆能[3] 谭建三[4] 

机构地区：[1]华西医大外科学教研室 [2]华西医大生物医学工程研究室 [3]华西医大外科实验室 [4]华西医大公共卫生学院病理学教研室

出　　处：《华西医科大学学报》1990年第1期25-29,共5页Journal of West China University of Medical Sciences

基　　金：四川省科委资助课题

摘　　要：作者制成犬急性出血坏死性胰腺炎(AHNP)模型,并对其血液流变学变化进行了系统观察。发现在犬AHNP早期,其血液流变学即发生显著异常,并随病程进展而加重,导致胰腺微循环障碍,使胰腺炎病变不断恶化;使用药物改善血液流变学异常后,胰腺炎病变即有明显好转。表明血液流变学异常在AHNP病变恶化过程中占有重要地位。并提示改善血液流变学的药物对AHNP的治疗是有益的。The hemorheologic alterations werestudied in experimental acute hemorrhagicnecrotizing pancreatitis (AHNP) which wasinduced by injection of 5% sodium tauro-cholate into the main pancreatic duct. Theresults showed that during the early stageof AHNP, all of hemorheologic parameterswere significantly elevated, and continuallyincreased at the rest intervals. The authorssuggested that the blood viscosity and hem-atocrit increase, red blood cells tend toaggregate, and erythrocyte deformation de-crease are the causation of pancreatic mi-crocirculatory disturbances and promotingpancreatic progressive necrosis. After usinglow molecular dextran and Salvia miltiorr-hizae, the hemorheologic alterations inAHNP were recovered, and the histologicobservation improved. Our dada indicatethe hemorheologic disturbances is one ofthe key factors in the pathogenesis ofAHNP.

关 键 词：胰腺炎 血液流变学 AHNP 病理 

分 类 号：R657.510.2[医药卫生—外科学]