白藜芦醇对小鼠免疫和抗氧化功能的影响  

The Effect of Resveratrol on Immune and antioxidative functions of Mice

作　　者：卓杰先[1] 张琳[2] 余学好[3] 

机构地区：[1]柳州师范高等专科学校体健系,广西柳州545004 [2]华南师范大学体育科学学院,广东广州510631 [3]怀化学院,湖南怀化418008

出　　处：《北京体育大学学报》2008年第9期1230-1232,共3页Journal of Beijing Sport University

摘　　要：目的:观察白藜芦醇对小鼠免疫和抗氧化功能的影响。方法:采用小鼠游泳训练的方法复制疲劳模型。30只健康昆明种小鼠随机分成3组,对照组、运动组、运动+白藜芦醇组,每组10只。游泳训练6周,6周后进行力竭游泳。测定小鼠腹腔巨噬细胞吞噬能力,胸腺和脾脏指数,小鼠血清超氧化物歧化酶(SOD)和丙二醛(MDA)含量。结果:白藜芦醇组与运动组比较,运动小鼠力竭时间明显延长,腹腔巨噬细胞的吞噬能力明显增高(P<0.05),脾脏指数、胸腺指数变化明显增加;小鼠血清超氧化物歧化酶(SOD)活性升高,血清丙二醛(MDA)含量下降。结论:白藜芦醇可提高机体免疫力和抗氧化功能。Objective ： The effects of resveratrol on immune and antioxidative functions of mice were observed. Methods. Thirty healthy male Kunming mice were selected and randczuly divided into 3 groups with 10 mice in each group： control group, exercise group;exercise ＋ resveratrol group. The swimming training is 6 weeds, carry on strength to exhaust and swim 6 weeks later. Measure Physical Performance , the ability to engulf chicken＇ s erythrocyte of little mouse＇ s abdominal cavity＇s macrophages, calculate the thymus and spleen index, the activity of SOD and the content of MDA. Results：The group of exercise ＋ resveratrol obviously lengthen the duration of exhaustive swimming, increase the ability of engulfing of abdominal cavity＇ s macrophages compared with exercise group, The impact on spleen index, thymic index is obvious improve. The activity of SOD was increased , but the content of MDA was decreased. Conclusion： Resveratrol could improve the immune and antioxidative functions of mice.

关 键 词：白藜芦醇 小鼠 免疫 抗氧化 

分 类 号：R285.5[医药卫生—中药学]