锌叶绿酸a的合成及初步临床应用  

Synthesis of Zinc Chlorophyllin a and Its Preliminary Clinical Application

作　　者：陶海鹏[1] 孙振贤 刘明蓉[1] 温贤敏[2] 

机构地区：[1]华西医大药学院有机化学教研室 [2]成都市第五人民医院

出　　处：《华西医科大学学报》1990年第3期341-343,共3页Journal of West China University of Medical Sciences

摘　　要：作者以蚕沙提取制得脱镁叶绿酸a,加锌盐合成锌叶绿酸a配合物,这在国内外尚属首创。小鼠急性毒性试验结果表明,本品毒性小,LD_(50)为324±40mg/kg。初步临床试用结果表明,本品有较好的生物活性,能消炎防痛、促进肉芽组织生成和上皮组织修复,对切口感染、口腔粘膜溃疡和浅度烧伤有明显疗效,值得深入研究。A method for synthesis of zinc chlo-rophyllin a (Ⅰ), a promisimg drug forclinical application, is presented. Takingsilkworm faeces as a raw material. chlo-rophyll was extracted with ethyl alcohol.After concentration the solid formed wasdissolved in petroleum ether and the solu-tion was subjected to column chromato-graphy to separate pheophytin a and chl-orophyll a. The products were dissolvedin ethyl ether and the Mg in the productswas stripped off with concentrated hydro-chloric acid,The excess hydrochloric acidin the solution was neutralized with am-monia solution and the mixture washydrolyzed with diluted hydrochloric acidto obtain pheophorbide a.then (Ⅰ) wassyn thesized with pheophorbide a and zincsalt. Th6 characteristics of (Ⅰ) and pheo-phorbide a were checked by IR. UV andelemental analyses. All results of pheo-phorbide a coincided with those values re-ported in literature. The acute toxicityof (Ⅰ) was tested in mice and the LD_(50)of (Ⅰ) was 324±40mg/kg. (Ⅰ) has beenapplied jn several hospitals for severalmonths.It has been found that (Ⅰ) hasoutstanding effects on burns and oral sep-sis and that it increases the growth ofgranulation tissue and epithelium remark-ably.

关 键 词：锌叶绿酸a 口腔粘膜溃疡 烧伤 

分 类 号：R977[医药卫生—药品]