利培酮对初发抑郁症转躁率的影响  

Effects of Risperidone on First Episode Depression

作　　者：钱建军[1] 何炳福[1] 石永扬 高赛男[1] 金海龙[1] 

机构地区：[1]浙江省绍兴市第七人民医院精神科,312000

出　　处：《医药导报》2008年第10期1188-1190,共3页Herald of Medicine

基　　金：绍兴市科技局基金资助项目(基金编号:2005193)

摘　　要：目的评价利培酮合并氟西汀对初发抑郁症转躁率的影响。方法139例初发抑郁症患者,分为治疗组68例和对照组71例。治疗组给予利培酮片,1周内渐加至3 mg.d-1,po;氟西汀胶囊20 mg.d-1,po。对照组给予氟西汀胶囊20 mg.d-1,po。治疗8周。评价方法为精神检查发现临床症状由抑郁状态转为躁狂状态、并经Bech-Rafaelsen躁狂量表(BRMS)测评≥6分确定为转躁。以不良反应量表(TESS)评分评价不良反应并记录发生的不良反应。结果两组总的转躁率、转躁出现时间、躁狂持续时间等方面组间比较,差异无显著性(P>0.05),但治疗组BRMS评分比对照组小,组间比较差异有显著性(P<0.05)。治疗组在年龄、性别、是否伴精神病性症状等方面组内区分比较,差异无显著性(P>0.05)。两组各时期TESS评分组间比较,差异无显著性(P>0.05)。结论利培酮合并氟西汀治疗初发抑郁症不能降低转躁率,对转躁出现时间、躁狂持续时间等方面无影响,但合并利培酮可降低转躁后躁狂的严重程度。合并利培酮治疗的患者的转躁率不受年龄、性别、是否伴精神病性症状等因素的影响,不会显著增加不良反应。Objective To assess the effects of risperidone combined with fluoxetine on first episode depression. Methods 139 patients with first episode depression were randomly divided into two groups , the treatment group （ n = 68 ）, received both PO 3 mg · d^-1 risperidone and 20 mg · d^-1 fluoxetine; the control group （n = 71 ）, treated with fluoxetine only , which were observed for 8 weeks. The evaluation criteria were defined as shifting from depression to mania （ ≥ 6 by Bech- Rafaelsen mania scale （BRMS）. The adverse reaction was assessed with TESS. Results No difference in switching rate, appearing time and duration between two groups was found （ P 〉 0.05 ）. And no difference in TESS was found （ P 〉 0.05 ） either. The BRMS was significant lower than that in the control group （ P 〈 0.05 ）. Conclusion Combination of risperidone with fiuoxetine cnuldnt influence switching rate, appearing time and duration of depression, but decrease severity of mania without obveriously adding more side effects.

关 键 词：利培酮 氟西汀 抑郁症 转躁率 

分 类 号：R971.43[医药卫生—药品] R749.41[医药卫生—药学]