2型糖尿病患者血清微量元素、血糖及体成分相关性分析  

Correlations of trace elements,glucose and body compositions in type 2 diabetics

作　　者：赵长峰[1] 王惠敏[2] 张俊黎[3] 冯丽[4] 刘言训[1] 邹凌燕[1] 胡琴静[1] 

机构地区：[1]山东大学公共卫生学院,济南250012 [2]山东大学齐鲁医院中心实验室 [3]山东省疾病预防控制中心 [4]山东省千佛山医院

出　　处：《卫生研究》2008年第5期600-601,605,共3页Journal of Hygiene Research

基　　金：山东省卫生厅科研基金资助(No.2005HZ037)

摘　　要：目的了解糖尿病患者与正常人群血清微量元素含量的差异,并探讨微量元素与糖尿病患者血糖、人体成分测量指标之间的关系。方法随机选取72名糖尿病患者作为病例组,64名健康体检者作为对照组。分别测量病例组和对照组的血清锌、硒、锰、镉、铁、铅、铜、镍、钴、锂、铬含量,铜锌比值,比较两组间差异,并与血糖及蛋白质含量、矿物质含量、脂肪含量、瘦体重、腰围、臀围等人体成分指标进行相关性分析。结果2型糖尿病患者血清锌、硒、铬含量显著低于对照组(P<0.05),血清铜含量则显著高于对照组(P<0.05),其他元素差异没有显著性。血清锌与血糖呈微弱负相关,铜与血糖呈正相关(P<0.01)。铜与腰围呈微弱正相关(P<0.01),锰与蛋白质含量、矿物质含量、臀围均呈微弱负相关(P<0.05)。结论纠正2型糖尿病患者体内存在着的微量元素代谢紊乱,对于糖尿病的治疗及预防并发症有重要价值。Objective To evaluate the difference in trace elements between diabetic and control groups,and to explore the correlations between trace elements and serum glucose,body compositions in patients with type 2 diabetes mellitus.Methods 72 diabetics and 64 controls are selected randomly.The level of serum trace elements,the ratio of copper,zinc were measured and compared between the two groups.A correlation was conducted for the serum trace elements,serum glucose and body compositions and 64 controls are selected randomly.Results There was a very significant difference in some serum trace elements level between diabetic and control groups（P〈0.01）.Serum zinc,selenium,chromium were significantly lower in diabetic group compared with the control group（P〈0.01）,copper was significantly higher（P〈0.01）.Negative correlations were showed between zinc and serum glucose,manganese and the content of protein,the content of trace elements,hip circumference.And positive correlations were showed between copper and serum glucose,copper and waist circumference.Conclusion It is concluded that there is trace elements metabolism disorder in patients with type 2 diabetes mellitus.The correction for this disorder might have significant value for the treatment of diabetics and prevention of complications.

关 键 词：2型糖尿病 微量元素 人体成分 铬 锌 血糖 

分 类 号：R587.1[医药卫生—内分泌] Q581[医药卫生—内科学]