不同海拔地区化疗后骨髓抑制的自身对照研究  

RANDOMIZED AND CONTROLLED STUDY OF CHEMOTHERAPY INDUCED MYELOID INHIBITION IN DIFFERENT ALTITUDE AREA

作　　者：李国元[1] 赵久达[1] 李建平[2] 刘海梅 鲍军海 耿排力[5] 

机构地区：[1]青海大学附属医院肿瘤内科,西宁810001 [2]青海大学附属医院血液科 [3]青海省海南州医院 [4]青海省海东行署民和县医院 [5]青海大学医学院

出　　处：《现代预防医学》2008年第19期3846-3847,3849,共3页Modern Preventive Medicine

摘　　要：[目的]探讨肿瘤患者在不同海拔地区化疗后骨髓抑制程度的差异及其临床意义。[方法]采用随机自身对照的方法,34例肿瘤患者以相同方案先后分别在海拔3015m地区和海拔1650m地区各进行2周期化疗,记录患者化疗后的外周血象,应用重组人粒细胞集落刺激因子(G-CSF)后的血象及G-CSF有效率,形成自身对照研究,比较前后的差异。[结果]28例患者(占82.36%)在海拔3015m地区化疗后出现较海拔1650m地区程度严重的骨髓抑制(相差Ⅰ-Ⅲ度),差异有统计学意义(P﹤0.01);G-CSF治疗粒细胞下降时海拔3015m地区有效率为64.71%,海拔1650m地区为87.50%,两者相比差异有统计学意义(P﹤0.05)。[结论]患者在海拔3015m地区化疗后出现骨髓抑制程度可能较海拔1650m地区严重,海拔3015m地区以G-CSF治疗粒细胞下降时有效率低于海拔1650m地区,其有关机理需要进一步研究。[Objective] To study the difference and cilinic significance of myeloid inhibition induced by chemotherapy m different altitude area. [Methods] 34 cancer patients confirmed by pathology or cytology were studied. All patients were treated with 2 cycles chemotherapy in 3 015m altitude area firstly, and then they were treated with 2 cycles chemotherapy by a same regimen in 1 650m altitude area, the counts of leucocyte, neutrophilicgra-nulocyte, thrombocytes and hemoglobin were observed after chemotherapy and therapied by G-CSF （granulocyte colony stimulating factor, G-CSF）. And then studied the difference of myeloid inhibition in two different altitude areas. [ Results] Tne myeloid inhibition induced by chemotherapy of 28 （82.36%） patients in 3 015m altitude area were serious than in 1 650m altitude area, 4 patients were reverse, still 2 patients were no significant difference. The effective rate of treating leukopenia with G-CSF in 3 015m altitude area （64.71%） was lower than in 1 650m altitude area （87.50%）. [Conclusion] It seems that myeloid inhibition induced by chemotherapy in 3 015m altitude area is serious than in 1650m altitude area, and the effective rate of G-CSF to leucopenia in 3 015m area is lower than in 1 650m altitude area. Its reason still needs to be studied further.

关 键 词：海拔 化疗 骨髓抑制 G-CSF 

分 类 号：R453[医药卫生—治疗学]