西拉普利联合美托洛尔治疗充血性心力衰竭的疗效研究  

CLINICAL EFFICACY OF CILAZAPRIL ACCOMPANIED WITH METOPROLOL FOR TREATMENT OF CONGESTIVE HEART FAILURE

作　　者：刘诗琼[1] 何月光[2] 何世利 赵生光[2] 张富娥[2] 迟伟[2] 

机构地区：[1]湖南永州职业技术学院医学院,永州425006 [2]永州市人民医院心血管内科 [3]道县人民医院心血管内科

出　　处：《现代预防医学》2008年第19期3848-3849,共2页Modern Preventive Medicine

摘　　要：[目的]探讨西拉普利联合美托洛尔治疗慢性充血性心力衰竭(CHF)的临床疗效。[方法]128例CHF病人随机分为治疗组和对照组。治疗组68例给予西拉普利0.5～2.5mg、美托洛尔6.25～50mg/d;对照组60例给予地高辛、利尿剂、硝苯地平治疗。两组疗程6个月。观察治疗前后两组病人的临床症状、超声心动图心功能指标、6min步行距离的变化及不良反应。[结果]治疗后治疗组临床总有效率为90.63%,对照组总有效率为68.75%,治疗前后相比两组LVEF、SV、CI、6min步行的距离均有显著改善(P﹤0.01),治疗组LVEF、CI及6min步行距离的改善优于对照组。[结论]西拉普利联合美托洛尔治疗CHF可以增强疗效。[Objective] To study the clinical therapeutic efficacy of Cilazapril accompanied with Metoprolol for treatment congestive heart failure （CHF）. [Methods] Random controlled trial was employed. We divided 128 patients with CHF into the treatment group （n = 68） and the control group （n = 60）. The clinical therapeutic efficacy. LVEF, SV, CI, 6min walk trial and adverse reactions were analyzed. [Results] The clinical prognosis and LVEF, SV, CI. 6min walk trail of the patients in the two groups were all significantly ameliorated comparing with those Of the patients before treatment （P 〈 0.01 ）, improvement of symptoms in the treatment group was better than that in the control group. [Conclusion] Cilazapfil accompanied with Metoprolol possesses obvious effect in treating patients with CHF.

关 键 词：西拉普利 美托洛尔 充血性心力衰竭 

分 类 号：R969.4[医药卫生—药理学]