医院病原菌的分布及耐药性分析  

DRUG RESISTANCE AND DISTRIBUTION OF NOSOCOMIAL INFECTION PATHOGENS

作　　者：孔俊峰[1] 王兵[1] 田二军 郭燕冰[1] 雷璐[1] 

机构地区：[1]河南省平顶山市第一人民医院检验科,平顶山467000

出　　处：《现代预防医学》2008年第19期3860-3862,共3页Modern Preventive Medicine

摘　　要：[目的]通过对某院住院患者中分离的所有致病菌进行分析,了解住院患者感染的病原菌分布特点和细菌的耐药状况,为临床合理使用抗生素提供依据。[方法]用常规方法分离鉴定病原菌,用K-B法做药物敏感试验。[结果]从2004年8月～2007年8月,共检出病原菌2672株,其中革兰阴性杆菌2071株,占77.5%,革兰阳性球菌601株,占22.5%,检出的前7位细菌分别为大肠埃希菌,克雷伯菌属,铜绿假单胞菌,凝固酶阴性葡萄球菌,金黄色葡萄球菌,鲍曼不动杆菌和肠球菌属。大肠埃希菌中ESBLs的检出率为57.8%,克雷伯菌属中ESBLs的检出率为74.2%,MRSA的检出率为16%,MRCNS的检出率为75.2%。[结论]了解该院引起感染的病原菌分布特点及耐药性监测,合理使用抗菌药物以减少耐药菌株的产生和医院感染的暴发流行。[Objective] To investigate the distribution and antibiotic resistance of pathogens isolated in Pingdingshan hospital. [Methods] After genus identification, bacterial susceptibility test was carried out using Kirby-Bauer disk method. [Results] A total of 2 672 clinical isolates were collected from August of 2004 to August of 2007, including 2 071 （77.5%） strains of gram-negative bacilli, 601 （22.5%） strains of gram-positive cocci. The most frequently isolated bacteria were E.eoli, Klebsierlla, P.aeruginosa, CONS （eoagulase negative staphylococcus）, S.aureus, A baumanil and Enterecoceus. About 57.8% of the E.coli isolates and 74.2% of klebsierlla isolates produced ESBLs. The prevalence of MRSA was 16% .The prevalence of MRCNS was 75.2%. [Conclusion] Studying the distribution and antibiotic resistance of pathogens isolated in hospital can effectively control nosocomial outbreak infections and reduce emergence of resistant pathogens.

关 键 词：病原菌 抗菌药物 耐药性 

分 类 号：R37[医药卫生—病原生物学]