吡咯并喹啉醌对急性放射性皮肤损伤大鼠机体自由基的清除作用  

Effect of pyrroloquinoline quinone on free radical in rats with radiation-induced skin injury

作　　者：吴祁生[1] 王建浩[1] 周迎会[1] 秦芳[1] 沈力[1] 吴士良[1] 

机构地区：[1]苏州大学基础医学与生物科学学院生物化学与分子生物学教研室,生化工程研究所,江苏苏州215123

出　　处：《江苏大学学报（医学版）》2008年第5期403-404,406,共3页Journal of Jiangsu University：Medicine Edition

基　　金：国防重点子项目基金资助(A3820060130)

摘　　要：目的:探讨高能电子射线照射大鼠急性皮肤损伤后,吡咯并喹啉醌(pyrroloquinoline quinone,PQQ)对放射损伤后皮肤和血清中自由基的清除作用。方法:采用电子直线加速器照射制作动物模型,以PQQ口服和辐照区喷射的给药方式,观察皮肤、血清中NOS,MDA和SOD含量的改变。结果:与辐照未给药组大鼠相比,应用PQQ的大鼠皮肤、血清中的MDA和NOS显著下降(P<0.05),但高于正常组大鼠(P<0.05);皮肤中SOD含量明显升高(P<0.05),但低于正常组大鼠(P<0.05),血清中SOD变化不明显。结论:PQQ能有效提高自由基清除酶系活性,部分清除电子直线加速器照射后产生的自由基,但达不到正常水平。Objective： To investigate PQQ scavenging free radicals in skin and serum of SD rats after linear accelerator radiation acute skin injury. Methods： The animal model of linear accelerator radiation injury was established, by PQQ oral administrations and jetting administrations, the contents of MDA, NOS, SOD in skin and serum were measured. Results： After PQQ administrations, to PQQ not-treating group, the contents of MDA and NOS decreased, were higher than the normal group （ P 〈 0.05 ） ; while the contents of SOD in skin increased, were lower than the normal group （P 〈 0.05 ）, the changes of SOD in serum had no significance. Conclusion： PQQ can effectively improve the activities of the free radical scavenging enzymes, partly decrease free radicals produced by linear accelerator radiation, but can not reach the normal level.

关 键 词：吡咯并喹啉醌 电子直线加速器照射 放射损伤 自由基 

分 类 号：R454[医药卫生—治疗学]