辛伐他汀对大鼠高肺血流所致肺动脉高压的干预研究  

Effect of Simvastatin on pulmonary artery hypertension induced by high pulmonary blood flow

作　　者：王兴东[1] 严文华[1] 文德[1] 

机构地区：[1]苏州大学附属儿童医院病理科,江苏苏州215003

出　　处：《江苏大学学报（医学版）》2008年第5期407-409,共3页Journal of Jiangsu University：Medicine Edition

摘　　要：目的:观察高肺血流导致肺动脉高压时肺血管病理改变,并了解辛伐他汀(Simvastatin)对肺动脉高压的干预作用。方法:对大鼠行腹主动脉-下腔静脉分流术,建立高肺血流所致肺动脉高压的动物模型,给予辛伐他汀2mg.kg-1.d-1干预11周后进行肺动脉压力测定,检测肺小动脉百分比,肺中、小型肌性动脉血管壁肌层厚度占外径的百分比(WT%)、血管壁肌层面积占血管总面积的百分比(WA%)以及肺动脉血管阻塞得分(vascular occlusionscore,VOS),并与正常组和对照组比较。结果:辛伐他汀能较好地降低肺动脉压力,降低肺肌性动脉百分比,降低WT%和WA%并能较好地阻止肺动脉血管阻塞。结论:辛伐他汀对高肺血流导致的肺动脉高压有较好的干预作用。Objective： To observe the change of pathology in pulmonary vascular when pulmonary hypertension induced by high pulmonary blood flow happens and comprehend the intervention effects of Simvastatin in pulmonary hypertension. Methods： Abdominal aorta-inferior vena cava shunting was made in rats to establish animal model of pulmonary hypertension induced by high pulmonary blood flow, Simvastatin with dose of 2 mg · kg^-1 · d^- 1 interfered for 11 weeks. And then, pulmonary arterial pressure, tri-type pulmonary arteriole percentage, ratio of vascular wall area/total vascular area（ WA% ） and ratio of vascular wall thickness/vascular external diameter （WT%） of pulmonary meta, ell-type arterial and vascular occlusion score （VOS） of pulmonary arteriole are determined. These were compared with those of nomal and control groups rats. Results： Simvastatin can decrease all of the pulmonary arterial pressure and tri-type pulmonary arteriole percentage, WA%, WT% and the VOS of pulmonary arteriole better. Conclusion： Simvatatin had better effect to intervent pulmonary hypertension induced by high pulmonary blood flow.

关 键 词：肺动脉高压 辛伐他汀 高肺血流 

分 类 号：R725.4[医药卫生—儿科]