微电极立体定向手术脑组织实时识别技术研究  

Research on Real-time Recognition Technology of Brain Tissue by MER-based Stereotactic Localization Surgery

作　　者：曹清华[1] 钱志余[1] 刘新文[1] 杨天明[2] 程业果[1] 

机构地区：[1]南京航空航天大学生物医学工程系,江苏南京210016 [2]东南大学附属中大医院,江苏南京210009

出　　处：《计算机测量与控制》2008年第9期1290-1291,1294,共3页Computer Measurement &Control

基　　金：国家自然科学基金资助项目(30671997)

摘　　要：针对目前帕金森病损毁手术中,神经外科医生无法准确实时识别和判断脑组织内部边界以及微电极所在神经核团的位置,对临床微电极记录帕金森病患者的神经放电信号进行研究;利用数学分形理论中的盒子维数理论进行分析,提出了客观定量的识别组织边界的方法,提高了组织定位精度;经过临床神经外科专家论证和大鼠实验结果表明,该方法可有效地识别出沿微电极针道上脑组织核团的变化,判定组织边界,该方法可用于临床神经外科手术中辅助定位导向。Intraoperative analysis of the posilion of microelectrode in the brain tissue only depends on experiences and subjective interpre ration of microeletrode recording discharge of neurons during neurosurgery for Parkinson＇s disease. Based on much research of microelectrode recordings, a method is given of objectively recognizing of brain tissue border during neurosurgery. This method uses the factor of box di mension theory. According to neurosurgeou＇s argumentation and animal experiment, this method is validated to identify the change of the brain tissue along microelectrode track and recognize tissue border. This method can be used to guide pallidotomy stereotactic localization neurosurgery.

关 键 词：帕金森 微电极 盒子维 小波变换 

分 类 号：TP391.5[自动化与计算机技术—计算机应用技术] R742[自动化与计算机技术—计算机科学与技术]