卡维地洛治疗老年轻中度原发性高血压疗效观察  

Clinical study of carvedilol in treatment of mild to moderate essential hypertension

作　　者：李学文[1] 张继红[1] 吴振军[1] 魏亚[1] 

机构地区：[1]武警医学院附属医院心血管内科,天津市300162

出　　处：《实用老年医学》2008年第5期379-381,共3页Practical Geriatrics

摘　　要：目的本研究以高选择性β受体阻滞剂比索洛尔为对照药，研究了卡维地洛治疗轻中度原发性高血压的临床疗效及安全性。方法选择轻中度原发性高血压患者60例，分别随机给予卡维地洛和比索洛尔口服治疗。结果2组在治疗2周时诊室血压均有所下降，在治疗6～8周末下降最明显，并维持至24周。卡维地洛组和比索洛尔组降压总有效率分别为93．3％和90％，总显效率分别为70％和56．7％。卡维地洛主要的不良反应有头晕（13％）、乏力（2％）、嗜睡（2％）。在服药过程中逐渐减轻，无因药物不良反应而终止者。结论本研究中的原发性高血压患者每日口服1次卡维地洛12．5～50mg，降压疗效明显，耐受性及安全性好。Objective To compare the anti-hypertension efficacy and the safety of 12. 5 - 50 mg carvedilol for mild to moderate essential hypertension. Methods Sixty patients were enrolled in this clinical study. Patients randomly took 12. 5 - 50 mg carvedilol tablet per day or 2. 5 - 10 mg bisoprolol tablet per day for 24 weeks. Results The clinic blood pressure of the two groups decreased at the end of two weeks of treatment, and the decrease showed most significant at the end of 6 - 8 weeks of treatment. The blood pressure maintained the same level to the end of 24 week. The reduction of blood pressure was 19.7/11.4 mmHg in carvedilol group, compared with 16. 6/9. 1 mmHg in bisoprolol group. The overall efficacy rate of eavedilol therapy and hisoprolol therapy was 93.3% and 90% , respectively. The rate of significant efficiency was 70% and 56. 7% in two groups,respectively. Carvedilol was well-tollerated with less side effects which included dizziness （13%） ,tiredness （2%）, and drowsiness （2%）. There were no patients withdrawing from the study because of side effects. Conclusions Carvedilol is effective and safe in patients with mild to moderate essential hypertension with a dose of 12. 5 -50 mg once per day as mono-therapy.

关 键 词：原发性高血压 卡维地洛 比索洛尔 

分 类 号：R544.1[医药卫生—心血管疾病]