Poly(HEMA-co-AAm)水凝胶对氯霉素的缓释作用(英文)  

Delayed release of chloramphenicol from poly(2-hydroxyethylmethacrylate-co-acrylamide) hydrogels

作　　者：崔英德 黎新明 

机构地区：[1]School of Chemistry and Chemical Engineering, Zhongkai University of Agricultureand Engineering, Guangzhou 510225, Guangdong, China

出　　处：《化工学报》2008年第9期2416-2418,共3页CIESC Journal

基　　金：the Natural Science Foundation of Guangdong Province (5300978)

摘　　要：Introduction The success of the therapy with ophthalmic drugsstrongly depends on achieving enough drug concentration on the cornea for a sufficient period of time,but the typical deliveryIntroduction The success of the therapy with ophthalmic drugs strongly depends on achieving enough drug concentration on the cornea for a sufficient period of time, but the typical delivery of drugs by eye-drops which currently account for more than 90G of all ophthalmic formulations is very inefficient and in some instances leads to serious side effects^[1-3]. Soft contact lenses have been proposed as a new vehicle for ophthalmic drug delivery^[4]. Theoretical simulation predicted that delivery of ophthalmic drugs by contact lenses is about 35 times more efficient than by eyedrops^[5]. Other benefits include convenience, no blinding of the eye, eliminating side-effects, better rate of release over time, and so on. Poly （2-hydroxyethylmethacrylate-co-acrylamide） hydrogels have been synthesized by bulk free-radical copolymerization for soft contact lens^[6]. In this paper, delayed release of chloramphenicol from the hydrogels was investigated. Chemical structures of chloramphenicol, zhydroxyethylmethacrylate （HEMA） and acrylamide （AAm） are shown in Fig. 1.

关 键 词：丙烯酰胺 氯霉素 化学分析 眼药 

分 类 号：O633.22[理学—高分子化学] S859.796[理学—化学]