家族聚集性慢性乙型肝炎的病毒前C区和基本核心启动子变异与临床病理的关系  

Relationship between hepatic histological alterations and hepatitis B virus basic core promoter/precore mutations of family assemble chronic hepatitis B

作　　者：杨友国[1] 刘成永[1] 王春颖[1] 王骥[1] 钱秀梅[1] 孙庆[1] 侯远沛 

机构地区：[1]江苏徐州市传染病医院,江苏省徐州市221004

出　　处：《世界华人消化杂志》2008年第26期2997-3000,共4页World Chinese Journal of Digestology

摘　　要：目的:分析家族聚集性慢性乙型肝炎的基因变异特征和肝组织病理学改变的关系.方法:选择家族聚集性慢性乙型肝炎112例作实验组和非家族聚集性慢性乙型肝炎110例作对照组;用基因芯片法检验前C1896和BCP1762、1764双突变;并肝组织活检进行肝组织炎症活动度计分和肝纤维化计分.结果:实验组BCPT1762/A1764双突变率显著高于对照组(χ2=4.5626,P=0.0044);实验组炎症评分显著高于对照组(u=6.3397,P=0.0000);家族聚集性慢性乙型肝炎者中单独BCPT1762/A1764双突变者炎症计分显著高于与无此类位点变异者和单独前C区1896变异者(t'=8.0111,7.958,t'α=2.1651,2.059,均P<0.05).结论:家族聚集慢性乙型肝炎肝组织炎症计分和纤维化计分较高,与BCP1762和1764的变异率较高有关.AIM： To study the relationship between hepatic histological alterations and hepatitis B virus gene mutations of family assemble chronic hepatitis B. METHODS： A total of 112 chronic Hepatitis B patients with family assemble features were selected as the experimental group, and 110 chronic hepatitis B patients without family assemble features were taken as control group. Basic core promoter/precore mutations were detected using genechip technology, and liver tissue inflammation grade and liver fibrosis grade were detected by liver biopsy. RESULTS： The double mutation rate of basal core promoter T1762/A1764 in experimental group was significantly higher than in control group （χ^2 = 4.5626, P = 0.0044）; the liver tissue inflammation grade in experimental group was significantly higher than in control group （u = 6.3397, P = 0.0000）; the liver tissue inflammation grade of family assemble chronic hepatitis B with only basal core promoter T1762/A1764 mutations was significantly higher than without such site mutation but only precore mutations（t＇ = 8.0111, 7.958, t＇α = 2.1651, 2.059, all P 〈 0.05）. CONCLUSION： The higher grade of liver tissue inflammation and liver fibrosis in patients with family assemble chronic hepatitis B is associated with the higher mutation rate of basal core promoter T1762/A1764.

关 键 词：乙型肝炎病毒 基因型 变异 家族聚集感染 

分 类 号：R512.62[医药卫生—内科学] R735.1[医药卫生—临床医学]