中国四城市15家医院门诊病例2型糖尿病合并症与生存质量关系研究  

The impact of complication on quality of life among diabetic patients in urban China

作　　者：刘兆兰[1] 付朝伟[1] 栾荣生[2] 詹思延[3] 陈维清[4] 王伟炳[1] 徐飚[1] 

机构地区：[1]复旦大学公共卫生学院流行病学教研室,上海200032 [2]四川大学华西公共卫生学院流行病学教研室 [3]北京大学公共卫生学院流行病学教研室 [4]中山大学公共卫生学院流行病学教研室

出　　处：《中华流行病学杂志》2008年第10期1029-1033,共5页Chinese Journal of Epidemiology

摘　　要：目的探讨城市人群2型糖尿病合并症与患者生存质量的关系。方法采用横断面调查的方法，从4个大城市15家医院门诊募集现患病例，采用问卷调查结合实验室检测的方法收集资料。分别运用t检验、方差分析和广义线性方程分析合并症与2型糖尿病患者生存质量的关系。结果合并症患者生存质量各维度得分均低于无合并症患者（得分降低4．68～16．06），合并症对患者生存质量各维度影响不同，对生理职能（降低22．45％）和情感职能（降低16．28％）影响较大，对生理机能（降低5．61％）和精神健康（降低6．65％）影响相对较小，合并症患者生存质量较无合并症患者总体低11．02％。随着合并症数量增加，患者生存质量逐渐降低，患者每增加1种合并症，其生存质量各维度得分平均降低2．82～10．33分。结论有合并症患者生存质量总体低于无合并症患者；随着合并症数量增加，患者生存质量逐渐下降，预防和减少患者合并症的发生对提高糖尿病患者的生存质量至关重要。Objective To explore the impact of chronic complications of type 2 diabetic mellitus （T2DM） on quality of life （QOL） among T2DM outpatients in urban China. Methods A cross-sectional study was carried out in 1524 T2DM outpatients recruited from 15 hospitals in 4 major cities of China. Questionnaire interviews were used to collect data on general characters and complications of T2DM. SF-36 questionnaire （version 1 ） was used and self-completed by patients under the help from interviewers for those having difficulties in reading. T test, one-way ANOVA and generalized linear model were used to explore the association between complications of T2DM and quality of life. Results Complication was a significant predictor leading to poorer SF-36 subscale scores（decreased by 4.68-16.06 scores） and two summary scores （PCS,MCS）. The scores of role-physical subseale （decreased by 22.45% ） and role-emotional subscale （decreased by 16.28% ） decreased much more than the other subscales in patients with complication. Overall, QOL was reduced by 11.02 % in patients with complication. The QOL had a gradual decrease with the increasing number of complications. The average scores descended from 2.82 to 10.33 in the eight subscales with the increase of one complication. Conclusion Having complication or multiple complications seemed to be predictors of poor QOL among T2DM outpatients.

关 键 词：2型糖尿病 合并症 生存质量 

分 类 号：R587.1[医药卫生—内分泌]