血清甘胆酸测定对于早期诊断妊娠期肝内胆汁瘀积症的临床意义  

Clinical significance of serum cholyglycine as an early sign of diagnostic importance in intrahepatic cholestasis of pregnancy

作　　者：朱贝利[1] 林莲初[1] 姜宏[1] 王永珍[1] 周红 

机构地区：[1]中国人民解放军第105医院,合肥230031

出　　处：《中国优生与遗传杂志》1997年第6期53-54,共2页Chinese Journal of Birth Health & Heredity

摘　　要：我院于1994年1月至1995年12月，采用放射免疫测定法（PIA）检测了846例孕妇血清甘胆酸（CG）浓度，其中58例确诊为妊娠期肝内胆汁瘀积症（ICP），CG正常值上限为3400／μg／L，ICP患者平均浓度为26031．8μg／L。阳性检出率达100％，发病率占同期住院分娩的4．9％（58：1182）。测定血清中CG和ALT是诊断ICP的主要实验室依据，血中CG值的升高先于瘙痒症的出现和ALT的升高。因此，CGRIA可以作为早期诊断ICP的指标，在CG异常组中动态观察临床和实验室各项指标的变化，加强产前、产时的胎儿监护，选择适当的分娩方式，降低围产儿死亡率。The serum cholyglycine (CG) levels in 846 cases of pregnant women from January 1994 to De cember 1995 were detected by RIA. of these, 58 cases were intrahepatic cholestasis of pregnancy (ICP). They accounted for 4. 9 % of the inpatient deliveries (58: 1182). The mean of CG in patients with ICP was 26031. 8 μg/L and CG level in all cases exceeded the mean of normal pregnancies (2536.7μg/L). CG level and ALT activily are the main laboratory findings of diagnostic impor tance for ICP. Increased CG level occurs earlier than pruritus, therefore it may be used as an early diagnostic parameter. In abnormal CG group, con tinuously clinical and laboratory observation, pre natal and intrapartum fetal monitoring were mandatory for determining the appropriate way of delivery.

关 键 词：甘胆酸 妊娠 肝内胆汁瘀积症 血清 

分 类 号：R714.255[医药卫生—妇产科学]