新生儿感染性疾病粒细胞集落刺激因子水平的测定  

Measurement of granulocyte-colony-stimulation factor of levels in the neonatal with infection dieases

作　　者：许豫英[1] 李迎伟[1] 

机构地区：[1]常州市第二人民医院儿科,213003

出　　处：《中国优生与遗传杂志》1997年第6期73-74,共2页Chinese Journal of Birth Health & Heredity

摘　　要：采用酶联免疫吸附试验（ELISA）测定180例新儿感染性疾病血清粒细胞集落刺激因子（G－GSF）水平，同时作血培养、C反应蛋白（CRP）、白细胞计数。结果表明：阳性率分别为：G－CSF73．9％、CRP50．5％、血培养21．1％。G－CSF阳性率明显高于后二者，差异显著（P均＜0．05）。败血症组、其他感染组、肺炎组的G－CSF阳性率分别为93．9％、85．1％、51．7％。粒细胞值＞10×109／L，G－CSF阳性组达81．2％，阴性组仅18．8％，尤其在抗感染治疗以前意义更大。提示应用ELISA技术测定G－CSF阳性率高，G－CSF水平对鉴定新生儿细菌感染具有较高的敏感性和实用价值。Measurement of granulocyte-colony- stimulating factor (G-CSF ) of the levels in 180 cases neonatal with infection diseases by using applica tion of enzyme linked immunoassays (ELISA ).The blood culture, CRP and blood reutine were ditermined meantime. The results showed the pos itive rate was 73. 9% in the G-CSF, 50. 5% in the CRP, 21.1 % in the blood culture. The positive rales was higher in G-CSF than the CRP and blood culture, there are great significant difference (P＜0.05). The G-CSF Positive rates of neonatal with septicaemia other infection and pneumonia are 93.9% , 85. 1 %, 57. 5% respectively. In the absolute nutriPhil counts 10×109/L G-CSF positive was 81. 2 % negative was only 18. 8%,especially before anti-infections treatment. The results suggested that the positive rate was higher in G-CSF use of ELISA method. We conclude that measurement of G-CSF of levels is more sensitivity and practicable in the neonatal with bacterium infedtions.

关 键 词：粒细胞集落 刺激因子 新生儿感染 测定 

分 类 号：R722.130.4[医药卫生—儿科]