恬心汤对家兔急性心力衰竭模型的保护和治疗作用  

Preventive and Therapeutic Effect of Tianxin Decoction on Rabbits with Acute Heart Failure

作　　者：张凤华[1] 张建平[2] 吴明华[2] 楚立[2] 

机构地区：[1]河北医科大学中西医结合学院,石家庄050091 [2]河北医科大学基础课教学部

出　　处：《河北中医药学报》2008年第3期5-7,共3页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：河北省科技厅科技攻关资助项目:No 06276102D-27

摘　　要：目的:探讨恬心汤对家兔急性心衰模型的保护和治疗作用。方法:以纯种新西兰兔为研究对象,随机分为溶剂对照组、造模前后灌服药物组(观察组)和造模后药物治疗组共3组,用恒速滴注戊巴比妥钠的方法建立兔急性心力衰竭模型,测定各组造模成功时造模剂用量及造模时间,观察血流动力学指标的变化情况。结果:①恬心汤能使戊巴比妥钠所致家兔急性心力衰竭模型形成所需的时间和用药量明显增加,与对照组和空白组相比较,差异有显著性(P<0.01);②各组指标用药后有回升趋势,但速度与程度有所不同,并且随着时间的推移,上升趋势的差异渐趋明显。血流动力学指标lv±dp/dtmax、lv+dp/dtmax、lv-dp/dtmax在药后60 min开始出现,组间差异有显著性(P<0.01);LVSP和t-dp/dtmax分别在药后60 min和90 min才开始显示组间差异(P<0.05)。结论:恬心汤对兔急性心力衰竭模型形成具有保护作用;能通过改善心室舒缩功能,降低外周阻力,改善心衰程度,对急性心力衰竭具有实验性治疗作用。Objective:to explore the preventive and therapeutic effects of Tianxin Decoction(TXD) on rabbits with acute heart failure.Methods: 24 New Zealand pure-bred rabbits were randomly divided into three groups: A,B and C.Group A was orally administrated with TXD before and after modeling,Group B with purified water before modeling and TXD after modeling,Group C with purified water before and after modeling.The differences of modeling time and dosage of pentobarbital sodium between groups were compared;hemodynamic parameters before and after administration were detected.Results:(1) The modeling time and dosage of pentobarbital sodium were remarkably increased in Group A,differences were significant compared with the other two groups(P<0.01);(2) All the hemodynamic indications showed a recovering trend in 3 groups at different rates and to different extent.The recovering trend increased with administration time.lv±dp/dtmax lv+dp/dtmax and lv-dp/dtmax appeared 60 minutes after administration with significant difference between groups(P<0.01);significant difference of LVSP and t-dp/dtmax between groups appeared 60 and 90 minutes after administration(P<0.05).Conclusion: TXD has the preventive effect on acute heart failure;it exerts certain therapeutic effect by enhancing cardiac systolic/diastolic function and byreducing peripheral resistance.

关 键 词：恬心汤 家兔 心力衰竭 血流动力学 

分 类 号：R285.5[医药卫生—中药学]