磷酸肌酸治疗新生儿缺氧缺血性脑病合并心肌损害的临床研究  

Creatine phosphate in treatment of neonateswit hypoxic ischemic encephalopathy merged with myocardial in jury

作　　者：吴丽燕[1] 黄辉文[1] 郭梁[1] 

机构地区：[1]珠海市妇幼保健院新生儿科,广东珠海519000

出　　处：《国际医药卫生导报》2008年第19期10-13,共4页International Medicine and Health Guidance News

摘　　要：目的探讨磷酸肌酸治疗新生儿缺氧缺血性脑病（HIE）合并心肌损害的疗效。方法82例HIE合并心肌损害的患儿随机分为治疗组（42例）和对照组（40例）。两组常规治疗相同，对照组用ATP，VitC，治疗组在此基础上加用磷酸肌酸。对两组患儿的心电图和心肌酶谱恢复正常率、神经行为评分（NB—NA）．主要症状与体征恢复时间及住院时间等进行比较分析。结果治疗组患者的心电图恢复正常率、心肌酶谱恢复正常率、NBNA评分、症状体征恢复时间及住院时间与对照组比较差异均有统计学意义（P〈0．05）。结论磷酸肌酸钠治疗HIE合并心肌损害疗效显著，安全有效。Objective To observe the effect of creatine Phosphate in treatment of new -born babies with hypoxic-ischemic encephalopathy （HIE） complicated by myocardial injury. Methods 82 HIE neonates complicated by myocardial injury were randomly divided into treatment group （n=42） and control group （n=40）.The treatmet group were treaed with creatine Phosphate while the control group with complex ATP, VitC injection beside that. Results Recovery of EC6 and myocardial enzymes as well as clinical present ations were more rapid in the treatment group than in the control group, and NBNA scores on the 5th day and the lOth day increased markedly in the theatment group compared with those in the control group （P 〈 0.05）.Conclusion Creatine phosphate has obvious efficiency in the theatment of HIE complicated with myocardial injury.

关 键 词：磷酸肌酸 新生儿 缺氧缺血性脑病 心肌损害 

分 类 号：R722[医药卫生—儿科] R742[医药卫生—临床医学]