急性冠状动脉综合征患者血清抵抗素水平与冠状动脉病变的相关性研究  

Correlation between serum resistin levels and coronary lesions in patients with acute coronary syndrome

作　　者：王浩[1] 何作云[2] 曹剑[1] 高凌云[2] 隆敏[2] 

机构地区：[1]解放军总医院南楼心血管一科,北京100853 [2]第三军医大学新桥医院

出　　处：《中华老年心脑血管病杂志》2008年第10期740-743,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家自然科学基金(30100069)

摘　　要：目的探讨急性冠状动脉综合征（ACS）患者血清抵抗素水平与冠状动脉病变严重程度之间的相关性。方法选择因胸痛住院的患者220例，根据病史、体检及冠状动脉造影结果将患者分为正常对照组（67例）、稳定性心绞痛（SAP）组（70例）和ACS组（83例）。检测患者血脂、外周血白细胞、高敏C反应蛋白（hs-CRP）和血清抵抗素水平，并均经冠状动脉造影评价冠状动脉狭窄程度和病变血管数目。结果ACS组患者血清抵抗素水平显著高于SAP组和正常对照组[（1．18±0．48）μg／L vs （0．66±0．40）μg／L vs （0．49±0．40）μg／L，P〈0．01]，仅在ACS组中，血清抵抗素水平与外周血白细胞水平（r=0．347，P=0．001）和hs—cRP水平（r=0．262，P=0．004）呈显著正相关。血清抵抗素水平随狭窄〉50％的冠状动脉数目的增多而升高（P〈O．01），logistic回归分析显示，血清抵抗素水平是ACS强的危险因素（OR=29．132，95％CI：10．939～77．581，P=0．000）。结论血清抵抗素水平与炎性反应和冠状动脉病变严重程度密切相关，是ACS强的危险预测因素。Objective To investigate the correlation between serum resistin levels and severity of coronary lesions in patients with acute coronary syndrome（ACS）. Methods A total of 220 consecutive patients, who were admitted to the cardiology department of Xin Qiao Hospital of the Third Military Medical University between November 2005 and December 2006, were divided into normal control group, stable angina pectoris（SAP） group, and ACS group. Fasting serum resistin concentration was measured with ELISA, and metabolic variables were measured with routine clinical laboratory methods. Results Resistin levels in ACS group were significantly higher than those in SAP and normal control groups （P〈0.01）. Only in ACS group, serum resistin levels were remarkably correlated with WBC values （r = 0. 347,P = 0. 001）and hs-CRP （r = 0. 262, P =0. 004）. Furthermore, Serum resistin levels increased with increasing the number of 〉50% stenotic coronary vessels. Multinomial logistic regression analysis demonstrated that serum resistin was a strong risk factor for ACS （OR =29. 132,95% CI. 10. 939--77. 581, P=0. 000）. Conclusion These findings suggest the potential role of resistin in the development of atherosclerosis and especially its involvement in the progress of ACS.

关 键 词：冠状动脉疾病 冠状血管造影术 C反应蛋白质 心绞痛 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]