血清淀粉样蛋白A和白细胞介素-18与2型糖尿病及合并大血管病变的关系  

Relationship between serum levels of serum amyloid A and interleukin-18 and pathogenesis of macrovascular complication in type 2 diabetes mellitns

作　　者：胡礼仪[1] 张高明[1] 李志沭[1] 陈慧芹[2] 杨莉[1] 许森林[1] 葛林[1] 

机构地区：[1]江苏省沭阳县人民医院检验科,223600 [2]江苏省沭阳县人民医院内分泌科,223600

出　　处：《中国医师进修杂志（内科版）》2008年第10期37-39,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨血清淀粉样蛋白A（SAA）、白细胞介素（IL）-18与2型糖尿病（他DM）及其合并大血管病变的关系。方法将65例T2DM患者（T2DM组）分为T2DM无并发症组（34例）和T2DM合并大血管病变组（31例），另选取30例健康体检者作为对照组。采用ELISA法测定SAA和IL-18水平，并进行相关性分析。结果T2DM组患者SAA、IL-18水平[（3．09±0．96）mg／L和（98．8±36．4）ng／L]显著高于对照组[（1．06±0．45）mg／L和（58．9±15．6）ng／L]，差异均有统计学意义（P〈0．05），T2DM合并大血管病变组患者SAA、IL-18水平[（6．34±1．52）mg／L和（141．2±48．3）ng/L]与T2DM无并发症组患者[（2．65±0．39）mg／L，（80．2±20．1）ng／L]比较差异均有统计学意义（P〈0.05）。另外相关分析显示：SAA与IL-18呈正相关（r=0．615，P〈o．05），SAA、IL-18分别与空腹血糖呈正相关（r=0．312、0．428，P〈0．05）。结论SAA、IL-18在T2DM及合并大血管病变患者中明显升高，在其发生和发展中具有重要的临床意义，可能是T2DM合并大血管病变的重要危险因素。Objective To investigate the serum amyloid A （SAA） and interleukin-18（IL-18） concentration in the pathogenesis of type 2 diabetes mellitus （T2DM） and its macrovascular complications. and study the relation between them. Methods ELISA was used to assay serum SAA and IL-18 levels in 65 T2DM patients （including 31 cases with maerovascular complications ） and 30 healthy controls. Results Serum SAA and IL-18 levels [ （3.09± 0.96）mg/L, （98.8 ±36.4 ）ng/L]were significantly elevated in patients with T2DM as compared with those in control subjects [ （ 1.06 ± 0.45）mg/L. （58.9 ±5.6）ng/L] （P 〈 0.05）. There was significant difference of SAA and IL-18 levels between T2DM patients with [ （ 6.34 ± 1.52） mg/L, （ 141.2 ± 48.3 ）ng/L ] and without maerovascukar complications [ （ 2.65 ±0.39 ）mg/L, （ 80.2 ± 20.1 ）ng/L]（P 〈 0.05 ）.Univariate linear regression analysis showed significant positive correlations between serum [L-18 with SAA （r = 0.615, P〈 0.05）, SAA, IL-18 and fasting blood glucose （FBG） had mutual positive correlations （r = 0.312, 0.428, P 〈 0.05, respectively）. Conclusions In patients with T2DM. serum SAA and IL-18 concentration is greater than in non-diabetic subjects. SAA and IL-18 play important roles in the initiation and development of T2DM. The study suggests that SAA and IL-18 might be an important independent risk factor.

关 键 词：淀粉样蛋白 白细胞介素18 糖尿病 2型 大血管病变 

分 类 号：R644[医药卫生—外科学] R541.4[医药卫生—临床医学]