鬼针草抗炎新成分的药理作用  

Pharmacological Effects or A New Anti-inflammatory Constituents in Spanishneedles(Bidens bipinnata)

作　　者：王建平[1] 张惠云[1] 秦红岩[1] 高玉敏[1] 周生海 王名州 

机构地区：[1]山东中医学院,济南250014

出　　处：《中草药》1997年第11期665-668,共4页Chinese Traditional and Herbal Drugs

基　　金：山东省自然科学基金

摘　　要：鬼针草中的新天然成分──鬼针聚炔甙（bipinnatpolyacetylenicloside）能明显抑制巴豆油诱发的小鼠耳壳肿胀及蛋清性足肿胀，降低大鼠棉球肉芽肿重量，还能显著抑制小鼠毛细血管通透性和醋酸至炎的大鼠的白细胞游走，其抗炎效果大多与地塞米松组无显著差异甚至有的作用略强，鬼针草中的黄酮混晶也有较好的抗炎作用。Bipinnatpolyacetylenic loside── a new natural constituent isolated from Bidens bipinnata, produced sig nificant inhibitory effects on swelling of mice ear induced by croton oil and hind paw edema induced by egg wbite,decreased the weight of cotton pellet granuloma implanted in rats,and also greatly inhibited blood cap illary permeability of mice and leukocyte movement induced by acetic acid in rats. Compared with that of dex amethasone,no significant difference and even slightly more potent effects were observed. The flavones in B.bipinnata also exhibited better anti-inflammatory effects.

关 键 词：鬼针草 鬼针聚炔甙 抗炎作用 药理 

分 类 号：R282.710.5[医药卫生—中药学] R285.5[医药卫生—中医学]