固相萃取和毛细管气相色谱法定量测定血中普莫卡因和布他卡因  

Quantitative analysis of pramocaine and butacaine in blood by capillary gas chromatography with solid phase extraction

作　　者：胡绪英[1] 刘锋[1] 罗毅[1] 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《军事医学科学院院刊》1997年第4期283-284,共2页Bulletin of the Academy of Military Medical Sciences

摘　　要：采用Ｘ－５树脂固相萃取技术纯化与富集血中普莫卡因和布他卡因，并用毛细管气相色谱内标法定量测定。二者在２０～１０００ｎｇ范围内均有良好线性回归，本法提取回收率为８５％～９０％，ＲＳＤ为４．３％～５．０％。An analytical method for quantitation of pramocaine and butacaine in blood was established. Pramocaine and butacaine were purified and concentrated by solid phase extraction using X 5 resin and then determined quantitatively by gas chromatography with internal standard. The linearity for both drugs was sufficiently good for quantitative analysis in the range from 20 ng to 1 000 ng. The recovery rates of the extraction were in the range from 85% to 90% with RSD from 4.3% to 5.0%.

关 键 词：麻醉药 布他卡因 普莫卡因 固相萃取 气相色谱法 

分 类 号：R971.2[医药卫生—药品]